Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?

Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting different degrees of manifestations severity. It is caused by the transmission of more than 20 species of parasites of the <i>Leishmania</i> genus. Nevertheless, the disease remains on the priority li...

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Autores principales:	Luiz H. C. Assis, Débora Andrade-Silva, Mark E. Shiburah, Beatriz C. D. de Oliveira, Stephany C. Paiva, Bryan E. Abuchery, Yete G. Ferri, Veronica S. Fontes, Leilane S. de Oliveira, Marcelo S. da Silva, Maria Isabel N. Cano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Leishmania</i> spp. leishmaniases cell cycle telomeres telomerase Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/927f0b5654a844fcace37edf7dd4c067
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spelling	oai:doaj.org-article:927f0b5654a844fcace37edf7dd4c0672021-11-25T17:12:43ZCell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?10.3390/cells101131952073-4409https://doaj.org/article/927f0b5654a844fcace37edf7dd4c0672021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3195https://doaj.org/toc/2073-4409Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting different degrees of manifestations severity. It is caused by the transmission of more than 20 species of parasites of the <i>Leishmania</i> genus. Nevertheless, the disease remains on the priority list for developing new treatments, since it affects millions in a vast geographical area, especially low-income people. Molecular biology studies are pioneers in parasitic research with the aim of discovering potential targets for drug development. Among them are the telomeres, DNA–protein structures that play an important role in the long term in cell cycle/survival. Telomeres are the physical ends of eukaryotic chromosomes. Due to their multiple interactions with different proteins that confer a likewise complex dynamic, they have emerged as objects of interest in many medical studies, including studies on leishmaniases. This review aims to gather information and elucidate what we know about the phenomena behind <i>Leishmania</i> spp. telomere maintenance and how it impacts the parasite’s cell cycle.Luiz H. C. AssisDébora Andrade-SilvaMark E. ShiburahBeatriz C. D. de OliveiraStephany C. PaivaBryan E. AbucheryYete G. FerriVeronica S. FontesLeilane S. de OliveiraMarcelo S. da SilvaMaria Isabel N. CanoMDPI AGarticle<i>Leishmania</i> spp.leishmaniasescell cycletelomerestelomeraseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3195, p 3195 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Leishmania</i> spp. leishmaniases cell cycle telomeres telomerase Biology (General) QH301-705.5
spellingShingle	<i>Leishmania</i> spp. leishmaniases cell cycle telomeres telomerase Biology (General) QH301-705.5 Luiz H. C. Assis Débora Andrade-Silva Mark E. Shiburah Beatriz C. D. de Oliveira Stephany C. Paiva Bryan E. Abuchery Yete G. Ferri Veronica S. Fontes Leilane S. de Oliveira Marcelo S. da Silva Maria Isabel N. Cano Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
description	Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting different degrees of manifestations severity. It is caused by the transmission of more than 20 species of parasites of the <i>Leishmania</i> genus. Nevertheless, the disease remains on the priority list for developing new treatments, since it affects millions in a vast geographical area, especially low-income people. Molecular biology studies are pioneers in parasitic research with the aim of discovering potential targets for drug development. Among them are the telomeres, DNA–protein structures that play an important role in the long term in cell cycle/survival. Telomeres are the physical ends of eukaryotic chromosomes. Due to their multiple interactions with different proteins that confer a likewise complex dynamic, they have emerged as objects of interest in many medical studies, including studies on leishmaniases. This review aims to gather information and elucidate what we know about the phenomena behind <i>Leishmania</i> spp. telomere maintenance and how it impacts the parasite’s cell cycle.
format	article
author	Luiz H. C. Assis Débora Andrade-Silva Mark E. Shiburah Beatriz C. D. de Oliveira Stephany C. Paiva Bryan E. Abuchery Yete G. Ferri Veronica S. Fontes Leilane S. de Oliveira Marcelo S. da Silva Maria Isabel N. Cano
author_facet	Luiz H. C. Assis Débora Andrade-Silva Mark E. Shiburah Beatriz C. D. de Oliveira Stephany C. Paiva Bryan E. Abuchery Yete G. Ferri Veronica S. Fontes Leilane S. de Oliveira Marcelo S. da Silva Maria Isabel N. Cano
author_sort	Luiz H. C. Assis
title	Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
title_short	Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
title_full	Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
title_fullStr	Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
title_full_unstemmed	Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?
title_sort	cell cycle, telomeres, and telomerase in <i>leishmania</i> spp.: what do we know so far?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/927f0b5654a844fcace37edf7dd4c067
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Cell Cycle, Telomeres, and Telomerase in <i>Leishmania</i> spp.: What Do We Know So Far?

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