Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation

Cellular ERK activation occurs as discrete pulses but their relationship to upstream Ras signaling is still under debate. Here, the authors show that Ras signaling associated with cellular protrusions triggers pulsed ERK activation, thereby enabling cells to integrate chemical and mechanical stimuli...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jr-Ming Yang, Sayak Bhattacharya, Hoku West-Foyle, Chien-Fu Hung, T.-C. Wu, Pablo A. Iglesias, Chuan-Hsiang Huang
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/927f4aae162542e094c9ed33fbf33687
Tags:	Add Tag No Tags, Be the first to tag this record!

id	oai:doaj.org-article:927f4aae162542e094c9ed33fbf33687
record_format	dspace
spelling	oai:doaj.org-article:927f4aae162542e094c9ed33fbf336872021-12-02T14:39:27ZIntegrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation10.1038/s41467-018-07150-92041-1723https://doaj.org/article/927f4aae162542e094c9ed33fbf336872018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07150-9https://doaj.org/toc/2041-1723Cellular ERK activation occurs as discrete pulses but their relationship to upstream Ras signaling is still under debate. Here, the authors show that Ras signaling associated with cellular protrusions triggers pulsed ERK activation, thereby enabling cells to integrate chemical and mechanical stimuli.Jr-Ming YangSayak BhattacharyaHoku West-FoyleChien-Fu HungT.-C. WuPablo A. IglesiasChuan-Hsiang HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jr-Ming Yang Sayak Bhattacharya Hoku West-Foyle Chien-Fu Hung T.-C. Wu Pablo A. Iglesias Chuan-Hsiang Huang Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
description	Cellular ERK activation occurs as discrete pulses but their relationship to upstream Ras signaling is still under debate. Here, the authors show that Ras signaling associated with cellular protrusions triggers pulsed ERK activation, thereby enabling cells to integrate chemical and mechanical stimuli.
format	article
author	Jr-Ming Yang Sayak Bhattacharya Hoku West-Foyle Chien-Fu Hung T.-C. Wu Pablo A. Iglesias Chuan-Hsiang Huang
author_facet	Jr-Ming Yang Sayak Bhattacharya Hoku West-Foyle Chien-Fu Hung T.-C. Wu Pablo A. Iglesias Chuan-Hsiang Huang
author_sort	Jr-Ming Yang
title	Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
title_short	Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
title_full	Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
title_fullStr	Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
title_full_unstemmed	Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
title_sort	integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed erk activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/927f4aae162542e094c9ed33fbf33687
work_keys_str_mv	AT jrmingyang integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT sayakbhattacharya integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT hokuwestfoyle integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT chienfuhung integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT tcwu integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT pabloaiglesias integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation AT chuanhsianghuang integratingchemicalandmechanicalsignalsthroughdynamiccouplingbetweencellularprotrusionsandpulsederkactivation
_version_	1718390604374736896

Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation

Similar Items