Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach
Mark J Gallardo,1,2 Richard A Supnet,1 Iqbal Ike K Ahmed3 1El Paso Eye Surgeons, PA, El Paso, TX, USA; 2University of Texas Health Sciences Center, San Antonio, TX, USA; 3Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada Purpose: The aim of this study...
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Dove Medical Press
2018
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oai:doaj.org-article:92822ab4037e4b4eb180542b1b61265f2021-12-02T02:19:37ZViscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach1177-5483https://doaj.org/article/92822ab4037e4b4eb180542b1b61265f2018-10-01T00:00:00Zhttps://www.dovepress.com/viscodilation-of-schlemms-canal-for-the-reduction-of-iop-via-an-ab-int-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mark J Gallardo,1,2 Richard A Supnet,1 Iqbal Ike K Ahmed3 1El Paso Eye Surgeons, PA, El Paso, TX, USA; 2University of Texas Health Sciences Center, San Antonio, TX, USA; 3Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada Purpose: The aim of this study was to compare the 1-year efficacy and safety profile of ab-interno canaloplasty (ABiC) when performed as a stand-alone procedure or as an adjunct to cataract extraction in reducing IOP and glaucoma medication dependence.Patients and methods: This retrospective, comparative, consecutive case series included patients with uncontrolled primary open-angle glaucoma (POAG) who underwent ABiC as a stand-alone procedure or in conjunction with cataract extraction. Data were collected over a 12-month period. Primary outcome measures were mean lower IOP and mean number of glaucoma medications. Secondary endpoints included surgical and postsurgical complications and secondary interventions.Results: The study included 75 eyes of 68 patients (mean age: 73.7±9.9 years) with a mean baseline IOP of 20.4±4.7 mmHg on 2.8±0.9 medications, which reduced to 13.3±1.9 mmHg (n=73) on 1.1±1.1 medications at 12 months postoperative (both P<0.0001). At 12 months, 40% of eyes were medication free. In the ABiC/phacoemulsification subgroup (n=34 eyes), the mean IOP and medication use decreased from 19.4±3.7 mmHg on 2.6±1.0 medications preoperatively to 13.0±1.8 mmHg on 0.8±0.2 medications at 12 months (both P<0.001). In the stand-alone ABiC subgroup (n=41), the mean IOP and medication use decreased from 21.2±5.3 mmHg on 3.0±0.7 medications preoperatively to 13.7±1.9 mmHg on 1.3±1.1 medications at 12 months (P=0.001 and <0.001, respectively). No serious adverse events were recorded.Conclusion: These data demonstrate that ABiC was effective at reducing IOP and medication use in eyes with uncontrolled POAG with or without cataract surgery. Keywords: IOP, primary open-angle glaucoma, ab-interno canaloplasty, glaucoma medicationGallardo MJSupnet RAAhmed IIKDove Medical PressarticleIntraocular pressureprimary open-angle glaucomaab interno canaloplastyglaucoma medicationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2149-2155 (2018) |
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DOAJ |
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Intraocular pressure primary open-angle glaucoma ab interno canaloplasty glaucoma medication Ophthalmology RE1-994 |
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Intraocular pressure primary open-angle glaucoma ab interno canaloplasty glaucoma medication Ophthalmology RE1-994 Gallardo MJ Supnet RA Ahmed IIK Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| description |
Mark J Gallardo,1,2 Richard A Supnet,1 Iqbal Ike K Ahmed3 1El Paso Eye Surgeons, PA, El Paso, TX, USA; 2University of Texas Health Sciences Center, San Antonio, TX, USA; 3Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada Purpose: The aim of this study was to compare the 1-year efficacy and safety profile of ab-interno canaloplasty (ABiC) when performed as a stand-alone procedure or as an adjunct to cataract extraction in reducing IOP and glaucoma medication dependence.Patients and methods: This retrospective, comparative, consecutive case series included patients with uncontrolled primary open-angle glaucoma (POAG) who underwent ABiC as a stand-alone procedure or in conjunction with cataract extraction. Data were collected over a 12-month period. Primary outcome measures were mean lower IOP and mean number of glaucoma medications. Secondary endpoints included surgical and postsurgical complications and secondary interventions.Results: The study included 75 eyes of 68 patients (mean age: 73.7±9.9 years) with a mean baseline IOP of 20.4±4.7 mmHg on 2.8±0.9 medications, which reduced to 13.3±1.9 mmHg (n=73) on 1.1±1.1 medications at 12 months postoperative (both P<0.0001). At 12 months, 40% of eyes were medication free. In the ABiC/phacoemulsification subgroup (n=34 eyes), the mean IOP and medication use decreased from 19.4±3.7 mmHg on 2.6±1.0 medications preoperatively to 13.0±1.8 mmHg on 0.8±0.2 medications at 12 months (both P<0.001). In the stand-alone ABiC subgroup (n=41), the mean IOP and medication use decreased from 21.2±5.3 mmHg on 3.0±0.7 medications preoperatively to 13.7±1.9 mmHg on 1.3±1.1 medications at 12 months (P=0.001 and <0.001, respectively). No serious adverse events were recorded.Conclusion: These data demonstrate that ABiC was effective at reducing IOP and medication use in eyes with uncontrolled POAG with or without cataract surgery. Keywords: IOP, primary open-angle glaucoma, ab-interno canaloplasty, glaucoma medication |
| format |
article |
| author |
Gallardo MJ Supnet RA Ahmed IIK |
| author_facet |
Gallardo MJ Supnet RA Ahmed IIK |
| author_sort |
Gallardo MJ |
| title |
Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| title_short |
Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| title_full |
Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| title_fullStr |
Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| title_full_unstemmed |
Viscodilation of Schlemm’s canal for the reduction of IOP via an ab-interno approach |
| title_sort |
viscodilation of schlemm’s canal for the reduction of iop via an ab-interno approach |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/92822ab4037e4b4eb180542b1b61265f |
| work_keys_str_mv |
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| _version_ |
1718402542336999424 |