Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.

<h4>Objectives</h4>Chronic rhinosinusitis (CRS) is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high. This study investigates the delivery...

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Autores principales:	Winfried Möller, Uwe Schuschnig, Gülnaz Celik, Wolfgang Münzing, Peter Bartenstein, Karl Häussinger, Wolfgang G Kreyling, Martin Knoch, Martin Canis, Sven Becker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/928310112b434f988a85b98334e75b78
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spelling	oai:doaj.org-article:928310112b434f988a85b98334e75b782021-11-18T08:55:40ZTopical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.1932-620310.1371/journal.pone.0074991https://doaj.org/article/928310112b434f988a85b98334e75b782013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040372/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objectives</h4>Chronic rhinosinusitis (CRS) is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high. This study investigates the delivery efficiency of a pulsating aerosol in comparison to a nasal pump spray to the sinuses and the nose in healthy volunteers and in CRS patients before and after sinus surgery.<h4>Methods</h4>(99m)Tc-DTPA pulsating aerosols were applied in eleven CRSsNP patients without nasal polyps before and after sinus surgery. In addition, pulsating aerosols were studied in comparison to nasal pump sprays in eleven healthy volunteers. Total nasal and frontal, maxillary and sphenoidal sinus aerosol deposition and lung penetration were assessed by anterior and lateral planar gamma camera imaging.<h4>Results</h4>In healthy volunteers nasal pump sprays resulted in 100% nasal, non-significant sinus and lung deposition, while pulsating aerosols resulted 61.3+/-8.6% nasal deposition and 38.7% exit the other nostril. 9.7+/-2.0 % of the nasal dose penetrated into maxillary and sphenoidal sinuses. In CRS patients, total nasal deposition was 56.7+/-13.3% and 46.7+/-12.7% before and after sinus surgery, respectively (p<0.01). Accordingly, maxillary and sphenoidal sinus deposition was 4.8+/-2.2% and 8.2+/-3.8% of the nasal dose (p<0.01). Neither in healthy volunteers nor in CRS patients there was significant dose in the frontal sinuses.<h4>Conclusion</h4>In contrast to nasal pump sprays, pulsating aerosols can deliver significant doses into posterior nasal spaces and paranasal sinuses, providing alternative therapy options before and after sinus surgery. Patients with chronic lung diseases based on clearance dysfunction may also benefit from pulsating aerosols, since these diseases also manifest in the upper airways.Winfried MöllerUwe SchuschnigGülnaz CelikWolfgang MünzingPeter BartensteinKarl HäussingerWolfgang G KreylingMartin KnochMartin CanisSven BeckerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74991 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Winfried Möller Uwe Schuschnig Gülnaz Celik Wolfgang Münzing Peter Bartenstein Karl Häussinger Wolfgang G Kreyling Martin Knoch Martin Canis Sven Becker Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
description	<h4>Objectives</h4>Chronic rhinosinusitis (CRS) is a common chronic disease of the upper airways and has considerable impact on quality of life. Topical delivery of drugs to the paranasal sinuses is challenging, therefore the rate of surgery is high. This study investigates the delivery efficiency of a pulsating aerosol in comparison to a nasal pump spray to the sinuses and the nose in healthy volunteers and in CRS patients before and after sinus surgery.<h4>Methods</h4>(99m)Tc-DTPA pulsating aerosols were applied in eleven CRSsNP patients without nasal polyps before and after sinus surgery. In addition, pulsating aerosols were studied in comparison to nasal pump sprays in eleven healthy volunteers. Total nasal and frontal, maxillary and sphenoidal sinus aerosol deposition and lung penetration were assessed by anterior and lateral planar gamma camera imaging.<h4>Results</h4>In healthy volunteers nasal pump sprays resulted in 100% nasal, non-significant sinus and lung deposition, while pulsating aerosols resulted 61.3+/-8.6% nasal deposition and 38.7% exit the other nostril. 9.7+/-2.0 % of the nasal dose penetrated into maxillary and sphenoidal sinuses. In CRS patients, total nasal deposition was 56.7+/-13.3% and 46.7+/-12.7% before and after sinus surgery, respectively (p<0.01). Accordingly, maxillary and sphenoidal sinus deposition was 4.8+/-2.2% and 8.2+/-3.8% of the nasal dose (p<0.01). Neither in healthy volunteers nor in CRS patients there was significant dose in the frontal sinuses.<h4>Conclusion</h4>In contrast to nasal pump sprays, pulsating aerosols can deliver significant doses into posterior nasal spaces and paranasal sinuses, providing alternative therapy options before and after sinus surgery. Patients with chronic lung diseases based on clearance dysfunction may also benefit from pulsating aerosols, since these diseases also manifest in the upper airways.
format	article
author	Winfried Möller Uwe Schuschnig Gülnaz Celik Wolfgang Münzing Peter Bartenstein Karl Häussinger Wolfgang G Kreyling Martin Knoch Martin Canis Sven Becker
author_facet	Winfried Möller Uwe Schuschnig Gülnaz Celik Wolfgang Münzing Peter Bartenstein Karl Häussinger Wolfgang G Kreyling Martin Knoch Martin Canis Sven Becker
author_sort	Winfried Möller
title	Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
title_short	Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
title_full	Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
title_fullStr	Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
title_full_unstemmed	Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
title_sort	topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/928310112b434f988a85b98334e75b78
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Topical drug delivery in chronic rhinosinusitis patients before and after sinus surgery using pulsating aerosols.

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