Clinical case of Guillain-Barré syndrome associated with COVID-19

Background: The coronavirus infection caused by SARS-Cov-2 is characterized by a damage to many organs and systems of the human body. To date, convincing information has been obtained about the involvement of various parts of the nervous system in the pathological process in patients with COVID-19....

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Autores principales:	Elena V. Shirshova, Vladimir V. Knaub, Vladimir P. Baklaushev
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	guillain-barré syndrome clinical features sars-cov-2 novel coronavirus infection covid-19 thrombotic manifestations immunoglobulin Medicine R
Acceso en línea:	https://doaj.org/article/9286c905124f4addae57a16c76bdc94b
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spelling	oai:doaj.org-article:9286c905124f4addae57a16c76bdc94b2021-11-30T18:15:21ZClinical case of Guillain-Barré syndrome associated with COVID-192220-30952618-862710.17816/clinpract72264https://doaj.org/article/9286c905124f4addae57a16c76bdc94b2021-07-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/72264/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627Background: The coronavirus infection caused by SARS-Cov-2 is characterized by a damage to many organs and systems of the human body. To date, convincing information has been obtained about the involvement of various parts of the nervous system in the pathological process in patients with COVID-19. Among the most frequently described impairments, there are disorders of smell and taste, common disorders of the central nervous system, characterized by general cerebral symptoms, such as headache, asthenization, psychopathological disorders. One of the rare and severe forms of the peripheral nervous system damage in COVID-19 is Guillain-Barre syndrome (GBS), characterized by acute post-infectious inflammatory polyneuropathy with an autoimmune etiology. Clinical case description. We present a clinical case of GBS associated with COVID-19. The disease debuted as a peripheral tetraparesis with a progredient course of up to 21 days. Systemic administration of immunoglobulin stopped the disease progression. The association of GBS with COVID-19 was clarified a month after the disease onset, when bilateral polysegmental pneumonia was diagnosed, and a high level of IgG to the S-protein of SARS-CoV-2 was found, 3 times higher than the level of IgM, which indicated the duration of the disease was not less than three weeks. Conclusion: The GBS development upon infection with SARS-CoV-2 may precede the lung damage. The debut of GBS during the COVID-19 pandemic requires the exclusion of the SARS-CoV-2 etiological role in each case.Elena V. ShirshovaVladimir V. KnaubVladimir P. BaklaushevEco-vectorarticleguillain-barré syndromeclinical featuressars-cov-2novel coronavirus infectioncovid-19thrombotic manifestationsimmunoglobulinMedicineRRUКлиническая практика , Vol 12, Iss 2, Pp 110-118 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	guillain-barré syndrome clinical features sars-cov-2 novel coronavirus infection covid-19 thrombotic manifestations immunoglobulin Medicine R
spellingShingle	guillain-barré syndrome clinical features sars-cov-2 novel coronavirus infection covid-19 thrombotic manifestations immunoglobulin Medicine R Elena V. Shirshova Vladimir V. Knaub Vladimir P. Baklaushev Clinical case of Guillain-Barré syndrome associated with COVID-19
description	Background: The coronavirus infection caused by SARS-Cov-2 is characterized by a damage to many organs and systems of the human body. To date, convincing information has been obtained about the involvement of various parts of the nervous system in the pathological process in patients with COVID-19. Among the most frequently described impairments, there are disorders of smell and taste, common disorders of the central nervous system, characterized by general cerebral symptoms, such as headache, asthenization, psychopathological disorders. One of the rare and severe forms of the peripheral nervous system damage in COVID-19 is Guillain-Barre syndrome (GBS), characterized by acute post-infectious inflammatory polyneuropathy with an autoimmune etiology. Clinical case description. We present a clinical case of GBS associated with COVID-19. The disease debuted as a peripheral tetraparesis with a progredient course of up to 21 days. Systemic administration of immunoglobulin stopped the disease progression. The association of GBS with COVID-19 was clarified a month after the disease onset, when bilateral polysegmental pneumonia was diagnosed, and a high level of IgG to the S-protein of SARS-CoV-2 was found, 3 times higher than the level of IgM, which indicated the duration of the disease was not less than three weeks. Conclusion: The GBS development upon infection with SARS-CoV-2 may precede the lung damage. The debut of GBS during the COVID-19 pandemic requires the exclusion of the SARS-CoV-2 etiological role in each case.
format	article
author	Elena V. Shirshova Vladimir V. Knaub Vladimir P. Baklaushev
author_facet	Elena V. Shirshova Vladimir V. Knaub Vladimir P. Baklaushev
author_sort	Elena V. Shirshova
title	Clinical case of Guillain-Barré syndrome associated with COVID-19
title_short	Clinical case of Guillain-Barré syndrome associated with COVID-19
title_full	Clinical case of Guillain-Barré syndrome associated with COVID-19
title_fullStr	Clinical case of Guillain-Barré syndrome associated with COVID-19
title_full_unstemmed	Clinical case of Guillain-Barré syndrome associated with COVID-19
title_sort	clinical case of guillain-barré syndrome associated with covid-19
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/9286c905124f4addae57a16c76bdc94b
work_keys_str_mv	AT elenavshirshova clinicalcaseofguillainbarresyndromeassociatedwithcovid19 AT vladimirvknaub clinicalcaseofguillainbarresyndromeassociatedwithcovid19 AT vladimirpbaklaushev clinicalcaseofguillainbarresyndromeassociatedwithcovid19
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Clinical case of Guillain-Barré syndrome associated with COVID-19

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