Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability

Juntao Yin,1,* Cuiyu Xiang,1,* Peiqing Wang,1 Yuyun Yin,2 Yantao Hou3 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, Kaifeng, 2Department of Physiochemical Analysis, Henan Provincial Institute for Food and Drug Control, Zhengzhou, 3Department of Pharmaceutical Enginee...

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Autores principales:	Yin J, Xiang C, Wang P, Yin Y, Hou Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Baicalin nanoemulsions biocompatibility high-pressure homogenization hemp oil bioavailability. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9289689399274439969133c12f36627e
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spelling	oai:doaj.org-article:9289689399274439969133c12f36627e2021-12-02T00:35:52ZBiocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability1178-2013https://doaj.org/article/9289689399274439969133c12f36627e2017-04-01T00:00:00Zhttps://www.dovepress.com/biocompatible-nanoemulsions-based-on-hemp-oil-and-less-surfactants-for-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Juntao Yin,1,* Cuiyu Xiang,1,* Peiqing Wang,1 Yuyun Yin,2 Yantao Hou3 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, Kaifeng, 2Department of Physiochemical Analysis, Henan Provincial Institute for Food and Drug Control, Zhengzhou, 3Department of Pharmaceutical Engineering, Henan Vocational College of Applied Technology, Kaifeng, People’s Republic of China *These authors contributed equally to this work Abstract: Baicalein (BCL) possesses high pharmacological activities but low solubility and stability in the intestinal tract. This study aimed to probe the potential of nanoemulsions (NEs) consisting of hemp oil and less surfactants in ameliorating the oral bioavailability of BCL. BCL-loaded NEs (BCL-NEs) were prepared by high-pressure homogenization technique to reduce the amount of surfactants. BCL-NEs were characterized by particle size, entrapment efficiency (EE), in vitro drug release, and morphology. Bioavailability was studied in Sprague-Dawley rats following oral administration of BCL suspensions, BCL conventional emulsions, and BCL-NEs. The obtained NEs were ~90 nm in particle size with an EE of 99.31%. BCL-NEs significantly enhanced the oral bioavailability of BCL, up to 524.7% and 242.1% relative to the suspensions and conventional emulsions, respectively. BCL-NEs exhibited excellent intestinal permeability and transcellular transport ability. The cytotoxicity of BCL-NEs was documented to be low and acceptable for oral purpose. Our findings suggest that such novel NEs and preparative process provide a promising alternative to current formulation technologies and suitable for oral delivery of drugs with bioavailability issues. Keywords: baicalein, nanoemulsions, biocompatibility, high-pressure homogenization, hemp oil, bioavailabilityYin JXiang CWang PYin YHou YDove Medical PressarticleBaicalinnanoemulsionsbiocompatibilityhigh-pressure homogenizationhemp oilbioavailability.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2923-2931 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Baicalin nanoemulsions biocompatibility high-pressure homogenization hemp oil bioavailability. Medicine (General) R5-920
spellingShingle	Baicalin nanoemulsions biocompatibility high-pressure homogenization hemp oil bioavailability. Medicine (General) R5-920 Yin J Xiang C Wang P Yin Y Hou Y Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
description	Juntao Yin,1,* Cuiyu Xiang,1,* Peiqing Wang,1 Yuyun Yin,2 Yantao Hou3 1Department of Pharmaceutics, Huaihe Hospital Affiliated to Henan University, Kaifeng, 2Department of Physiochemical Analysis, Henan Provincial Institute for Food and Drug Control, Zhengzhou, 3Department of Pharmaceutical Engineering, Henan Vocational College of Applied Technology, Kaifeng, People’s Republic of China *These authors contributed equally to this work Abstract: Baicalein (BCL) possesses high pharmacological activities but low solubility and stability in the intestinal tract. This study aimed to probe the potential of nanoemulsions (NEs) consisting of hemp oil and less surfactants in ameliorating the oral bioavailability of BCL. BCL-loaded NEs (BCL-NEs) were prepared by high-pressure homogenization technique to reduce the amount of surfactants. BCL-NEs were characterized by particle size, entrapment efficiency (EE), in vitro drug release, and morphology. Bioavailability was studied in Sprague-Dawley rats following oral administration of BCL suspensions, BCL conventional emulsions, and BCL-NEs. The obtained NEs were ~90 nm in particle size with an EE of 99.31%. BCL-NEs significantly enhanced the oral bioavailability of BCL, up to 524.7% and 242.1% relative to the suspensions and conventional emulsions, respectively. BCL-NEs exhibited excellent intestinal permeability and transcellular transport ability. The cytotoxicity of BCL-NEs was documented to be low and acceptable for oral purpose. Our findings suggest that such novel NEs and preparative process provide a promising alternative to current formulation technologies and suitable for oral delivery of drugs with bioavailability issues. Keywords: baicalein, nanoemulsions, biocompatibility, high-pressure homogenization, hemp oil, bioavailability
format	article
author	Yin J Xiang C Wang P Yin Y Hou Y
author_facet	Yin J Xiang C Wang P Yin Y Hou Y
author_sort	Yin J
title	Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
title_short	Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
title_full	Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
title_fullStr	Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
title_full_unstemmed	Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
title_sort	biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/9289689399274439969133c12f36627e
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_version_	1718403632115744768

Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability

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