Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that increasing the activity of the pathway enhances the an...

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Autores principales:	Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas T. Vasu, Yiqing Zhang, Ayesha S. Khan, Stacy Lloyd, Adam T. Szafran, Subhamoy Dasgupta, David A. Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel E. Frigo, Lawrence Chan, Dean P. Edwards, Benny A. Kaipparettu, Nicholas Mitsiades, Nancy L. Weigel, Michael Mancini, Sean E. McGuire, Rohit Mehra, Michael M. Ittmann, Arul M. Chinnaiyan, Nagireddy Putluri, Ganesh S. Palapattu, George Michailidis, Arun Sreekumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
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spelling	oai:doaj.org-article:928bd0a4d45444ac89e49f796339b9e42021-12-02T14:40:15ZInhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer10.1038/ncomms116122041-1723https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e42016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11612https://doaj.org/toc/2041-1723The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that increasing the activity of the pathway enhances the anti-androgen response.Akash K. KaushikAli ShojaieKatrin PanzittRajni SonavaneHarene VenghatakrishnanMohan ManikkamAlexander ZaslavskyVasanta PutluriVihas T. VasuYiqing ZhangAyesha S. KhanStacy LloydAdam T. SzafranSubhamoy DasguptaDavid A. BaderFabio StossiHangwen LiSusmita SamantaXuhong CaoEfrosini TsoukoShixia HuangDaniel E. FrigoLawrence ChanDean P. EdwardsBenny A. KaipparettuNicholas MitsiadesNancy L. WeigelMichael ManciniSean E. McGuireRohit MehraMichael M. IttmannArul M. ChinnaiyanNagireddy PutluriGanesh S. PalapattuGeorge MichailidisArun SreekumarNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Akash K. Kaushik Ali Shojaie Katrin Panzitt Rajni Sonavane Harene Venghatakrishnan Mohan Manikkam Alexander Zaslavsky Vasanta Putluri Vihas T. Vasu Yiqing Zhang Ayesha S. Khan Stacy Lloyd Adam T. Szafran Subhamoy Dasgupta David A. Bader Fabio Stossi Hangwen Li Susmita Samanta Xuhong Cao Efrosini Tsouko Shixia Huang Daniel E. Frigo Lawrence Chan Dean P. Edwards Benny A. Kaipparettu Nicholas Mitsiades Nancy L. Weigel Michael Mancini Sean E. McGuire Rohit Mehra Michael M. Ittmann Arul M. Chinnaiyan Nagireddy Putluri Ganesh S. Palapattu George Michailidis Arun Sreekumar Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
description	The molecular alterations driving anti-androgen resistance in prostate cancer are unclear. Here, the authors show, using a network-based approach, that inhibition of the hexosamine biosynthetic pathway is necessary to develop resistance and that increasing the activity of the pathway enhances the anti-androgen response.
format	article
author	Akash K. Kaushik Ali Shojaie Katrin Panzitt Rajni Sonavane Harene Venghatakrishnan Mohan Manikkam Alexander Zaslavsky Vasanta Putluri Vihas T. Vasu Yiqing Zhang Ayesha S. Khan Stacy Lloyd Adam T. Szafran Subhamoy Dasgupta David A. Bader Fabio Stossi Hangwen Li Susmita Samanta Xuhong Cao Efrosini Tsouko Shixia Huang Daniel E. Frigo Lawrence Chan Dean P. Edwards Benny A. Kaipparettu Nicholas Mitsiades Nancy L. Weigel Michael Mancini Sean E. McGuire Rohit Mehra Michael M. Ittmann Arul M. Chinnaiyan Nagireddy Putluri Ganesh S. Palapattu George Michailidis Arun Sreekumar
author_facet	Akash K. Kaushik Ali Shojaie Katrin Panzitt Rajni Sonavane Harene Venghatakrishnan Mohan Manikkam Alexander Zaslavsky Vasanta Putluri Vihas T. Vasu Yiqing Zhang Ayesha S. Khan Stacy Lloyd Adam T. Szafran Subhamoy Dasgupta David A. Bader Fabio Stossi Hangwen Li Susmita Samanta Xuhong Cao Efrosini Tsouko Shixia Huang Daniel E. Frigo Lawrence Chan Dean P. Edwards Benny A. Kaipparettu Nicholas Mitsiades Nancy L. Weigel Michael Mancini Sean E. McGuire Rohit Mehra Michael M. Ittmann Arul M. Chinnaiyan Nagireddy Putluri Ganesh S. Palapattu George Michailidis Arun Sreekumar
author_sort	Akash K. Kaushik
title	Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
title_short	Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
title_full	Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
title_fullStr	Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
title_full_unstemmed	Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
title_sort	inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/928bd0a4d45444ac89e49f796339b9e4
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Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer

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