Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the pro...

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Autores principales:	Sílvia Porta, Yan Xu, Clark R. Restrepo, Linda K. Kwong, Bin Zhang, Hannah J. Brown, Edward B. Lee, John Q. Trojanowski, Virginia M.-Y. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92900ea31995481996608cd988369b83
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spelling	oai:doaj.org-article:92900ea31995481996608cd988369b832021-12-02T16:50:11ZPatient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo10.1038/s41467-018-06548-92041-1723https://doaj.org/article/92900ea31995481996608cd988369b832018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06548-9https://doaj.org/toc/2041-1723Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the process of seeding and spreading of TDP43 pathology in a spatio-temporal dependent manner in the brain.Sílvia PortaYan XuClark R. RestrepoLinda K. KwongBin ZhangHannah J. BrownEdward B. LeeJohn Q. TrojanowskiVirginia M.-Y. LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
description	Cell-to-cell transmission of TDP43 occurs in cell cultures and may contribute to pathological TDP43 propagation in FTLD-TDP. In this study, the authors demonstrate using mouse models that a single intracerebral injection of human brain-derived pathological TDP43 from FTLD-TDP cases initiates the process of seeding and spreading of TDP43 pathology in a spatio-temporal dependent manner in the brain.
format	article
author	Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee
author_facet	Sílvia Porta Yan Xu Clark R. Restrepo Linda K. Kwong Bin Zhang Hannah J. Brown Edward B. Lee John Q. Trojanowski Virginia M.-Y. Lee
author_sort	Sílvia Porta
title	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
title_short	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
title_full	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
title_fullStr	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
title_full_unstemmed	Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
title_sort	patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of tdp-43 pathology in vivo
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/92900ea31995481996608cd988369b83
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Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

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