Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

Statins are a wide category of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor drugs extensively prescribed for hypercholesterolemia. In fact, many studies showed beneficial effects of these agents on a variety of related illnesses, which include increased atherosclerotic plaque...

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Autores principales:	Mahshid Ataei, Basil D. Roufogalis, Prashant Kesharwani, Tannaz Jamialahmadi, Amirhossein Sahebkar
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197
Acceso en línea:	https://doaj.org/article/929467d5f37b4073bff2a00571c24c46
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spelling	oai:doaj.org-article:929467d5f37b4073bff2a00571c24c462021-11-15T01:19:26ZHarnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers1687-479X10.1155/2021/7265505https://doaj.org/article/929467d5f37b4073bff2a00571c24c462021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7265505https://doaj.org/toc/1687-479XStatins are a wide category of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor drugs extensively prescribed for hypercholesterolemia. In fact, many studies showed beneficial effects of these agents on a variety of related illnesses, which include increased atherosclerotic plaque stability, decreased proliferation of vascular smooth muscle, platelet aggregation, the dampening of vascular inflammation, and also anabolic effects on bone tissue. Therefore, these drugs are considered as pleiotropic agents having different clinical applications other than those for which they were initially developed. Controlled drug delivery is an efficient way of delivery in tissue engineering. Amongst different controlled release formulations, nanofibers are a novel, alternative, widely used agent because of their unique properties. These include their sustained release of drug, a high drug-loading capacity, flexible shapes with a high surface-to-volume ratio, and superior porosity. Electrospinning is an economic and a simple method employed to produce nanofibers. In this report, studies related to statin nanofiber applications have been reviewed and their results have been summarized. Four different applications of statin nanofibers have been reported, including bone generation, endothelial stenosis and thrombosis, peripheral nerve injury, and anti-inflammatory action. Studies carried out both in vitro and in vivo showed effectiveness of statins in bone healing, aneurysm, and the healing of sciatic nerve injury. In addition, statins showed apoptosis effects and anti-inflammatory effects, with dose-dependent reduction of IL-6 and dose-independent reduction of TNF-α. Despite these promising results, validation via clinical trials is yet to be performed. The scope of statins in their pleiotropic range of actions is still not completely explored, and studies are still needed to enlighten different useful aspects of such drugs.Mahshid AtaeiBasil D. RoufogalisPrashant KesharwaniTannaz JamialahmadiAmirhossein SahebkarHindawi LimitedarticleBiotechnologyTP248.13-248.65Inorganic chemistryQD146-197ENBioinorganic Chemistry and Applications, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197
spellingShingle	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197 Mahshid Ataei Basil D. Roufogalis Prashant Kesharwani Tannaz Jamialahmadi Amirhossein Sahebkar Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
description	Statins are a wide category of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor drugs extensively prescribed for hypercholesterolemia. In fact, many studies showed beneficial effects of these agents on a variety of related illnesses, which include increased atherosclerotic plaque stability, decreased proliferation of vascular smooth muscle, platelet aggregation, the dampening of vascular inflammation, and also anabolic effects on bone tissue. Therefore, these drugs are considered as pleiotropic agents having different clinical applications other than those for which they were initially developed. Controlled drug delivery is an efficient way of delivery in tissue engineering. Amongst different controlled release formulations, nanofibers are a novel, alternative, widely used agent because of their unique properties. These include their sustained release of drug, a high drug-loading capacity, flexible shapes with a high surface-to-volume ratio, and superior porosity. Electrospinning is an economic and a simple method employed to produce nanofibers. In this report, studies related to statin nanofiber applications have been reviewed and their results have been summarized. Four different applications of statin nanofibers have been reported, including bone generation, endothelial stenosis and thrombosis, peripheral nerve injury, and anti-inflammatory action. Studies carried out both in vitro and in vivo showed effectiveness of statins in bone healing, aneurysm, and the healing of sciatic nerve injury. In addition, statins showed apoptosis effects and anti-inflammatory effects, with dose-dependent reduction of IL-6 and dose-independent reduction of TNF-α. Despite these promising results, validation via clinical trials is yet to be performed. The scope of statins in their pleiotropic range of actions is still not completely explored, and studies are still needed to enlighten different useful aspects of such drugs.
format	article
author	Mahshid Ataei Basil D. Roufogalis Prashant Kesharwani Tannaz Jamialahmadi Amirhossein Sahebkar
author_facet	Mahshid Ataei Basil D. Roufogalis Prashant Kesharwani Tannaz Jamialahmadi Amirhossein Sahebkar
author_sort	Mahshid Ataei
title	Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
title_short	Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
title_full	Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
title_fullStr	Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
title_full_unstemmed	Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers
title_sort	harnessing therapeutic potentials of statins using nanofibrous carriers
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/929467d5f37b4073bff2a00571c24c46
work_keys_str_mv	AT mahshidataei harnessingtherapeuticpotentialsofstatinsusingnanofibrouscarriers AT basildroufogalis harnessingtherapeuticpotentialsofstatinsusingnanofibrouscarriers AT prashantkesharwani harnessingtherapeuticpotentialsofstatinsusingnanofibrouscarriers AT tannazjamialahmadi harnessingtherapeuticpotentialsofstatinsusingnanofibrouscarriers AT amirhosseinsahebkar harnessingtherapeuticpotentialsofstatinsusingnanofibrouscarriers
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Harnessing Therapeutic Potentials of Statins Using Nanofibrous Carriers

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