CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data

Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with which they analyse the TCGA and PCAWG datasets.

Guardado en:

Detalles Bibliográficos
Autores principales:	Judith Abécassis, Fabien Reyal, Jean-Philippe Vert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9296eac0f7114802a1105cd6046c1b10
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9296eac0f7114802a1105cd6046c1b10
record_format	dspace
spelling	oai:doaj.org-article:9296eac0f7114802a1105cd6046c1b102021-12-02T17:42:11ZCloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data10.1038/s41467-021-24992-y2041-1723https://doaj.org/article/9296eac0f7114802a1105cd6046c1b102021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24992-yhttps://doaj.org/toc/2041-1723Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with which they analyse the TCGA and PCAWG datasets.Judith AbécassisFabien ReyalJean-Philippe VertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Judith Abécassis Fabien Reyal Jean-Philippe Vert CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
description	Intratumour heterogeneity (ITH) and mutational signatures are typically analysed separately, even though they are not necessarily independent. Here, the authors present CloneSig, a tool for the joint estimation of ITH and mutational signatures, with which they analyse the TCGA and PCAWG datasets.
format	article
author	Judith Abécassis Fabien Reyal Jean-Philippe Vert
author_facet	Judith Abécassis Fabien Reyal Jean-Philippe Vert
author_sort	Judith Abécassis
title	CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
title_short	CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
title_full	CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
title_fullStr	CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
title_full_unstemmed	CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
title_sort	clonesig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9296eac0f7114802a1105cd6046c1b10
work_keys_str_mv	AT judithabecassis clonesigcanjointlyinferintratumorheterogeneityandmutationalsignatureactivityinbulktumorsequencingdata AT fabienreyal clonesigcanjointlyinferintratumorheterogeneityandmutationalsignatureactivityinbulktumorsequencingdata AT jeanphilippevert clonesigcanjointlyinferintratumorheterogeneityandmutationalsignatureactivityinbulktumorsequencingdata
_version_	1718379658262609920

CloneSig can jointly infer intra-tumor heterogeneity and mutational signature activity in bulk tumor sequencing data

Ejemplares similares