Cannabinoids modulate food preference and consumption in Drosophila melanogaster

Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids aff...

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Autores principales:	Jianzheng He, Alice Mei Xien Tan, Si Yun Ng, Menglong Rui, Fengwei Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9297ef9db7e54869acbd7fa6a6e5f29e
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spelling	oai:doaj.org-article:9297ef9db7e54869acbd7fa6a6e5f29e2021-12-02T11:37:18ZCannabinoids modulate food preference and consumption in Drosophila melanogaster10.1038/s41598-021-84180-22045-2322https://doaj.org/article/9297ef9db7e54869acbd7fa6a6e5f29e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84180-2https://doaj.org/toc/2045-2322Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.Jianzheng HeAlice Mei Xien TanSi Yun NgMenglong RuiFengwei YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu Cannabinoids modulate food preference and consumption in Drosophila melanogaster
description	Abstract Cannabinoids have an important role in regulating feeding behaviors via cannabinoid receptors in mammals. Cannabinoids also exhibit potential therapeutic functions in Drosophila melanogaster, or fruit fly that lacks cannabinoid receptors. However, it remains unclear whether cannabinoids affect food consumption and metabolism in a cannabinoid receptors-independent manner in flies. In this study, we systematically investigated pharmacological functions of various cannabinoids in modulating food preference and consumption in flies. We show that flies display preferences for consuming cannabinoids, independent of two important sensory regulators Poxn and Orco. Interestingly, phyto- and endo- cannabinoids exhibit an inhibitory effect on food intake. Unexpectedly, the non-selective CB1 receptor antagonist AM251 attenuates the suppression of food intake by endocannabinoids. Moreover, the endocannabinoid anandamide (AEA) and its metabolite inhibit food intake and promote resistance to starvation, possibly through reduced lipid metabolism. Thus, this study has provided insights into a pharmacological role of cannabinoids in feeding behaviors using an adult Drosophila model.
format	article
author	Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu
author_facet	Jianzheng He Alice Mei Xien Tan Si Yun Ng Menglong Rui Fengwei Yu
author_sort	Jianzheng He
title	Cannabinoids modulate food preference and consumption in Drosophila melanogaster
title_short	Cannabinoids modulate food preference and consumption in Drosophila melanogaster
title_full	Cannabinoids modulate food preference and consumption in Drosophila melanogaster
title_fullStr	Cannabinoids modulate food preference and consumption in Drosophila melanogaster
title_full_unstemmed	Cannabinoids modulate food preference and consumption in Drosophila melanogaster
title_sort	cannabinoids modulate food preference and consumption in drosophila melanogaster
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9297ef9db7e54869acbd7fa6a6e5f29e
work_keys_str_mv	AT jianzhenghe cannabinoidsmodulatefoodpreferenceandconsumptionindrosophilamelanogaster AT alicemeixientan cannabinoidsmodulatefoodpreferenceandconsumptionindrosophilamelanogaster AT siyunng cannabinoidsmodulatefoodpreferenceandconsumptionindrosophilamelanogaster AT menglongrui cannabinoidsmodulatefoodpreferenceandconsumptionindrosophilamelanogaster AT fengweiyu cannabinoidsmodulatefoodpreferenceandconsumptionindrosophilamelanogaster
_version_	1718395774487756800

Cannabinoids modulate food preference and consumption in Drosophila melanogaster

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