TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral...

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Autores principales: Dominik Wieland, Janine Kemming, Anita Schuch, Florian Emmerich, Percy Knolle, Christoph Neumann-Haefelin, Werner Held, Dietmar Zehn, Maike Hofmann, Robert Thimme
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/9297f10505a14ae8978a8c449887da65
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spelling oai:doaj.org-article:9297f10505a14ae8978a8c449887da652021-12-02T15:39:04ZTCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation10.1038/ncomms150502041-1723https://doaj.org/article/9297f10505a14ae8978a8c449887da652017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15050https://doaj.org/toc/2041-1723Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral therapy removes antigen exposure, and that these cells are responsive on re-exposure to antigen.Dominik WielandJanine KemmingAnita SchuchFlorian EmmerichPercy KnolleChristoph Neumann-HaefelinWerner HeldDietmar ZehnMaike HofmannRobert ThimmeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
description Virus-specific CD8+T cells lose effector function over the course of chronic infection, a process called ‘exhaustion’, but the fate of these cells after treatment-induced antigen elimination is unknown. Here the authors show that exhausted cells persist in patients even after direct-acting antiviral therapy removes antigen exposure, and that these cells are responsive on re-exposure to antigen.
format article
author Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
author_facet Dominik Wieland
Janine Kemming
Anita Schuch
Florian Emmerich
Percy Knolle
Christoph Neumann-Haefelin
Werner Held
Dietmar Zehn
Maike Hofmann
Robert Thimme
author_sort Dominik Wieland
title TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_short TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_full TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_fullStr TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_full_unstemmed TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
title_sort tcf1+ hepatitis c virus-specific cd8+ t cells are maintained after cessation of chronic antigen stimulation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/9297f10505a14ae8978a8c449887da65
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