Histopathology of optic nerve pit-associated maculopathy

John B Christoforidis, William Terrell, Frederick H DavidorfCollege of Medicine, The Ohio State University, Columbus, OH, USAPurpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous elevation of the macula and cavernous atrophy of...

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Autores principales:	Christoforidis JB, Terrell W, Davidorf FH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/929a07af848b4ec09f8fc0ae9839f8ce
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spelling	oai:doaj.org-article:929a07af848b4ec09f8fc0ae9839f8ce2021-12-02T03:23:42ZHistopathology of optic nerve pit-associated maculopathy1177-54671177-5483https://doaj.org/article/929a07af848b4ec09f8fc0ae9839f8ce2012-07-01T00:00:00Zhttp://www.dovepress.com/histopathology-of-optic-nerve-pit-associated-maculopathy-a10510https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483John B Christoforidis, William Terrell, Frederick H DavidorfCollege of Medicine, The Ohio State University, Columbus, OH, USAPurpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous elevation of the macula and cavernous atrophy of the optic nerve.Methods: An eye bank specimen found to have an optic nerve pit with serous elevation of the macula was grossly examined and photographed. The globe was processed for both light and scanning electron microscopy.Results: The scanning electron microscopic study of this eye with an optic nerve pit revealed holes in the diaphanous membrane overlying the nerve at the edge of the optic pit. Serial histopathology sections revealed a connection between the holes overlying the optic pit and the subretinal space via a schisis-like cavity in the retina.Conclusion: The discovery of an optic nerve pit with coexisting serous detachment of the macula in an eye bank eye and subsequent pathological evaluation provides support for current theories into the mechanism of the visual loss in this condition. Our finding supports syneretic vitreous to be the source of the subretinal fluid.Keywords: optic nerve pit, light microscopy, electron microscopy, retinal detachmentChristoforidis JBTerrell WDavidorf FHDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1169-1174 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Christoforidis JB Terrell W Davidorf FH Histopathology of optic nerve pit-associated maculopathy
description	John B Christoforidis, William Terrell, Frederick H DavidorfCollege of Medicine, The Ohio State University, Columbus, OH, USAPurpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous elevation of the macula and cavernous atrophy of the optic nerve.Methods: An eye bank specimen found to have an optic nerve pit with serous elevation of the macula was grossly examined and photographed. The globe was processed for both light and scanning electron microscopy.Results: The scanning electron microscopic study of this eye with an optic nerve pit revealed holes in the diaphanous membrane overlying the nerve at the edge of the optic pit. Serial histopathology sections revealed a connection between the holes overlying the optic pit and the subretinal space via a schisis-like cavity in the retina.Conclusion: The discovery of an optic nerve pit with coexisting serous detachment of the macula in an eye bank eye and subsequent pathological evaluation provides support for current theories into the mechanism of the visual loss in this condition. Our finding supports syneretic vitreous to be the source of the subretinal fluid.Keywords: optic nerve pit, light microscopy, electron microscopy, retinal detachment
format	article
author	Christoforidis JB Terrell W Davidorf FH
author_facet	Christoforidis JB Terrell W Davidorf FH
author_sort	Christoforidis JB
title	Histopathology of optic nerve pit-associated maculopathy
title_short	Histopathology of optic nerve pit-associated maculopathy
title_full	Histopathology of optic nerve pit-associated maculopathy
title_fullStr	Histopathology of optic nerve pit-associated maculopathy
title_full_unstemmed	Histopathology of optic nerve pit-associated maculopathy
title_sort	histopathology of optic nerve pit-associated maculopathy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/929a07af848b4ec09f8fc0ae9839f8ce
work_keys_str_mv	AT christoforidisjb histopathologyofopticnervepitassociatedmaculopathy AT terrellw histopathologyofopticnervepitassociatedmaculopathy AT davidorffh histopathologyofopticnervepitassociatedmaculopathy
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Histopathology of optic nerve pit-associated maculopathy

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