Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix

Sundas Maqsood,1,2 Kareem Elsawah,3 Navpreet Dhillon,1 Shady Soliman,3 Masara Laginaf,2 Vaishali Lodhia,2 Damian Lake,1 Samer Hamada,1 Mohamed Elalfy1– 3 1Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK; 2Eye Department, Maidstone and Turnbridge Wells Hospitals, Maidst...

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Autores principales:	Maqsood S, Elsawah K, Dhillon N, Soliman S, Laginaf M, Lodhia V, Lake D, Hamada S, Elalfy M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	persistent epithelial defects amniotic membrane derived dry matrix suture less amniotic membrane Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/929a404d26fa4cb9bbe9914f25ef5283
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spelling	oai:doaj.org-article:929a404d26fa4cb9bbe9914f25ef52832021-12-02T15:01:00ZManagement of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix1177-5483https://doaj.org/article/929a404d26fa4cb9bbe9914f25ef52832021-05-01T00:00:00Zhttps://www.dovepress.com/management-of-persistent-corneal-epithelial-defects-with-human-amnioti-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Sundas Maqsood,1,2 Kareem Elsawah,3 Navpreet Dhillon,1 Shady Soliman,3 Masara Laginaf,2 Vaishali Lodhia,2 Damian Lake,1 Samer Hamada,1 Mohamed Elalfy1– 3 1Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK; 2Eye Department, Maidstone and Turnbridge Wells Hospitals, Maidstone, UK; 3Cornea Department, Research Institute of Ophthalmology, Giza, EgyptCorrespondence: Mohamed Elalfy Tel +44 1342 414560Email m.elalfy@nhs.netObjective: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.Methods: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen® using OmniLenz® at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM.Results: A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4± 12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens–Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, acanthamoeba: 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population.Conclusion: AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects.Keywords: persistent epithelial defects, amniotic membrane derived dry matrix, suture less amniotic membraneMaqsood SElsawah KDhillon NSoliman SLaginaf MLodhia VLake DHamada SElalfy MDove Medical Pressarticlepersistent epithelial defectsamniotic membrane derived dry matrixsuture less amniotic membraneOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2231-2238 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	persistent epithelial defects amniotic membrane derived dry matrix suture less amniotic membrane Ophthalmology RE1-994
spellingShingle	persistent epithelial defects amniotic membrane derived dry matrix suture less amniotic membrane Ophthalmology RE1-994 Maqsood S Elsawah K Dhillon N Soliman S Laginaf M Lodhia V Lake D Hamada S Elalfy M Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
description	Sundas Maqsood,1,2 Kareem Elsawah,3 Navpreet Dhillon,1 Shady Soliman,3 Masara Laginaf,2 Vaishali Lodhia,2 Damian Lake,1 Samer Hamada,1 Mohamed Elalfy1– 3 1Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK; 2Eye Department, Maidstone and Turnbridge Wells Hospitals, Maidstone, UK; 3Cornea Department, Research Institute of Ophthalmology, Giza, EgyptCorrespondence: Mohamed Elalfy Tel +44 1342 414560Email m.elalfy@nhs.netObjective: To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.Methods: A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen® using OmniLenz® at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM.Results: A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4± 12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens–Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, acanthamoeba: 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population.Conclusion: AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects.Keywords: persistent epithelial defects, amniotic membrane derived dry matrix, suture less amniotic membrane
format	article
author	Maqsood S Elsawah K Dhillon N Soliman S Laginaf M Lodhia V Lake D Hamada S Elalfy M
author_facet	Maqsood S Elsawah K Dhillon N Soliman S Laginaf M Lodhia V Lake D Hamada S Elalfy M
author_sort	Maqsood S
title	Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
title_short	Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
title_full	Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
title_fullStr	Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
title_full_unstemmed	Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix
title_sort	management of persistent corneal epithelial defects with human amniotic membrane-derived dry matrix
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/929a404d26fa4cb9bbe9914f25ef5283
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Management of Persistent Corneal Epithelial Defects with Human Amniotic Membrane-derived Dry Matrix

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