Distinct methylation levels of mature microRNAs in gastrointestinal cancers

In cancer it is assumed that microRNAs recognise and regulate their targets uniformly. Here, the authors show that in gastrointestinal cancers methylation of microRNAs may impact their stability, and that levels of microRNA methylation are distinct in pancreatic cancer patients compared to healthy c...

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Autores principales:	Masamitsu Konno, Jun Koseki, Ayumu Asai, Akira Yamagata, Teppei Shimamura, Daisuke Motooka, Daisuke Okuzaki, Koichi Kawamoto, Tsunekazu Mizushima, Hidetoshi Eguchi, Shuji Takiguchi, Taroh Satoh, Koshi Mimori, Takahiro Ochiya, Yuichiro Doki, Ken Ofusa, Masaki Mori, Hideshi Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/929c4fb0ae134cfbbe776b9545d3494b
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spelling	oai:doaj.org-article:929c4fb0ae134cfbbe776b9545d3494b2021-12-02T15:35:18ZDistinct methylation levels of mature microRNAs in gastrointestinal cancers10.1038/s41467-019-11826-12041-1723https://doaj.org/article/929c4fb0ae134cfbbe776b9545d3494b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11826-1https://doaj.org/toc/2041-1723In cancer it is assumed that microRNAs recognise and regulate their targets uniformly. Here, the authors show that in gastrointestinal cancers methylation of microRNAs may impact their stability, and that levels of microRNA methylation are distinct in pancreatic cancer patients compared to healthy controls with potential diagnostic implications.Masamitsu KonnoJun KosekiAyumu AsaiAkira YamagataTeppei ShimamuraDaisuke MotookaDaisuke OkuzakiKoichi KawamotoTsunekazu MizushimaHidetoshi EguchiShuji TakiguchiTaroh SatohKoshi MimoriTakahiro OchiyaYuichiro DokiKen OfusaMasaki MoriHideshi IshiiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masamitsu Konno Jun Koseki Ayumu Asai Akira Yamagata Teppei Shimamura Daisuke Motooka Daisuke Okuzaki Koichi Kawamoto Tsunekazu Mizushima Hidetoshi Eguchi Shuji Takiguchi Taroh Satoh Koshi Mimori Takahiro Ochiya Yuichiro Doki Ken Ofusa Masaki Mori Hideshi Ishii Distinct methylation levels of mature microRNAs in gastrointestinal cancers
description	In cancer it is assumed that microRNAs recognise and regulate their targets uniformly. Here, the authors show that in gastrointestinal cancers methylation of microRNAs may impact their stability, and that levels of microRNA methylation are distinct in pancreatic cancer patients compared to healthy controls with potential diagnostic implications.
format	article
author	Masamitsu Konno Jun Koseki Ayumu Asai Akira Yamagata Teppei Shimamura Daisuke Motooka Daisuke Okuzaki Koichi Kawamoto Tsunekazu Mizushima Hidetoshi Eguchi Shuji Takiguchi Taroh Satoh Koshi Mimori Takahiro Ochiya Yuichiro Doki Ken Ofusa Masaki Mori Hideshi Ishii
author_facet	Masamitsu Konno Jun Koseki Ayumu Asai Akira Yamagata Teppei Shimamura Daisuke Motooka Daisuke Okuzaki Koichi Kawamoto Tsunekazu Mizushima Hidetoshi Eguchi Shuji Takiguchi Taroh Satoh Koshi Mimori Takahiro Ochiya Yuichiro Doki Ken Ofusa Masaki Mori Hideshi Ishii
author_sort	Masamitsu Konno
title	Distinct methylation levels of mature microRNAs in gastrointestinal cancers
title_short	Distinct methylation levels of mature microRNAs in gastrointestinal cancers
title_full	Distinct methylation levels of mature microRNAs in gastrointestinal cancers
title_fullStr	Distinct methylation levels of mature microRNAs in gastrointestinal cancers
title_full_unstemmed	Distinct methylation levels of mature microRNAs in gastrointestinal cancers
title_sort	distinct methylation levels of mature micrornas in gastrointestinal cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/929c4fb0ae134cfbbe776b9545d3494b
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Distinct methylation levels of mature microRNAs in gastrointestinal cancers

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