Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species ca...

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Autores principales:	Angeliki M. Andrianaki, Irene Kyrmizi, Kalliopi Thanopoulou, Clara Baldin, Elias Drakos, Sameh S. M. Soliman, Amol C. Shetty, Carrie McCracken, Tonia Akoumianaki, Kostas Stylianou, Petros Ioannou, Charalampos Pontikoglou, Helen A. Papadaki, Maria Tzardi, Valerie Belle, Emilien Etienne, Anne Beauvais, George Samonis, Dimitrios P. Kontoyiannis, Evangelos Andreakos, Vincent M. Bruno, Ashraf S. Ibrahim, Georgios Chamilos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/929e08b851964a52b6dd9b6ff495bee8
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spelling	oai:doaj.org-article:929e08b851964a52b6dd9b6ff495bee82021-12-02T16:56:36ZIron restriction inside macrophages regulates pulmonary host defense against Rhizopus species10.1038/s41467-018-05820-22041-1723https://doaj.org/article/929e08b851964a52b6dd9b6ff495bee82018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05820-2https://doaj.org/toc/2041-1723Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.Angeliki M. AndrianakiIrene KyrmiziKalliopi ThanopoulouClara BaldinElias DrakosSameh S. M. SolimanAmol C. ShettyCarrie McCrackenTonia AkoumianakiKostas StylianouPetros IoannouCharalampos PontikoglouHelen A. PapadakiMaria TzardiValerie BelleEmilien EtienneAnne BeauvaisGeorge SamonisDimitrios P. KontoyiannisEvangelos AndreakosVincent M. BrunoAshraf S. IbrahimGeorgios ChamilosNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angeliki M. Andrianaki Irene Kyrmizi Kalliopi Thanopoulou Clara Baldin Elias Drakos Sameh S. M. Soliman Amol C. Shetty Carrie McCracken Tonia Akoumianaki Kostas Stylianou Petros Ioannou Charalampos Pontikoglou Helen A. Papadaki Maria Tzardi Valerie Belle Emilien Etienne Anne Beauvais George Samonis Dimitrios P. Kontoyiannis Evangelos Andreakos Vincent M. Bruno Ashraf S. Ibrahim Georgios Chamilos Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
description	Mucormycosis is a life-threatening respiratory fungal infection that typically occurs in patients with abnormalities in iron metabolism. Here the authors show that iron restriction inside the phagosome of macrophages is an essential component of the host defense against Rhizopus, the main species causing mucormycosis.
format	article
author	Angeliki M. Andrianaki Irene Kyrmizi Kalliopi Thanopoulou Clara Baldin Elias Drakos Sameh S. M. Soliman Amol C. Shetty Carrie McCracken Tonia Akoumianaki Kostas Stylianou Petros Ioannou Charalampos Pontikoglou Helen A. Papadaki Maria Tzardi Valerie Belle Emilien Etienne Anne Beauvais George Samonis Dimitrios P. Kontoyiannis Evangelos Andreakos Vincent M. Bruno Ashraf S. Ibrahim Georgios Chamilos
author_facet	Angeliki M. Andrianaki Irene Kyrmizi Kalliopi Thanopoulou Clara Baldin Elias Drakos Sameh S. M. Soliman Amol C. Shetty Carrie McCracken Tonia Akoumianaki Kostas Stylianou Petros Ioannou Charalampos Pontikoglou Helen A. Papadaki Maria Tzardi Valerie Belle Emilien Etienne Anne Beauvais George Samonis Dimitrios P. Kontoyiannis Evangelos Andreakos Vincent M. Bruno Ashraf S. Ibrahim Georgios Chamilos
author_sort	Angeliki M. Andrianaki
title	Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
title_short	Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
title_full	Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
title_fullStr	Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
title_full_unstemmed	Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species
title_sort	iron restriction inside macrophages regulates pulmonary host defense against rhizopus species
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/929e08b851964a52b6dd9b6ff495bee8
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Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species

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