Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice

Cannabinoids (CBs), such as phytocannabinoids, synthetic CBs, and endogenous CBs, can be neuroprotective, rewarding, or aversive. The aversive effects of CBs may hinder their medical and recreational applications. It is unknown which type of CB receptors mediates the direct aversive effects of synth...

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Autores principales:	Jin Cong, Kangrong Lu, Wenjie Zou, Ziming Li, Zhipeng Guo, Xiangzhen Tong, Jiawei Zheng, Jianping Zhu, Shuji Li, Wangming Zhang, Yanwu Guo, Tian-Ming Gao, Rongqing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	astrocyte cannabinoid cannabinoid receptor conditioned place aversion cyclooxygenase-2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/929ee7a5809e4edc926b2280e71e6705
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spelling	oai:doaj.org-article:929ee7a5809e4edc926b2280e71e67052021-11-30T12:46:20ZAstroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice1662-510210.3389/fncel.2021.772549https://doaj.org/article/929ee7a5809e4edc926b2280e71e67052021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.772549/fullhttps://doaj.org/toc/1662-5102Cannabinoids (CBs), such as phytocannabinoids, synthetic CBs, and endogenous CBs, can be neuroprotective, rewarding, or aversive. The aversive effects of CBs may hinder their medical and recreational applications. It is unknown which type of CB receptors mediates the direct aversive effects of synthetic CB CP 55,940 which is an analog of Δ9-tetrahydrocannabinol, the major psychoactive component of marijuana. In this study, we address this question by taking the advantage of systematic type 1 CB receptor (CB1R) knockout mice and conditional reinstatement of this receptor only in astrocytes. We show that CP 55,940 at a concentration of 1 mg/kg induces conditioned place aversion (CPA) and the CPA effect of CP 55,940 is mediated by the astroglial CB1Rs. Inhibiting cyclooxygenase-2 (COX-2) eliminates CP 55,940-induced CPA in mice that only express CB1Rs in astrocytes. These findings conclude that CPA effect of CP 55,940 is mediated by the astroglial CB1Rs through COX-2 signaling, suggesting that selective COX-2 inhibition or precise isolation of astroglial CB1R activity may be the strategy for treating aversive response of medical and recreational administrations of marijuana.Jin CongKangrong LuWenjie ZouZiming LiZhipeng GuoXiangzhen TongJiawei ZhengJiawei ZhengJianping ZhuShuji LiWangming ZhangYanwu GuoTian-Ming GaoTian-Ming GaoRongqing ChenRongqing ChenRongqing ChenFrontiers Media S.A.articleastrocytecannabinoidcannabinoid receptorconditioned place aversioncyclooxygenase-2Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	astrocyte cannabinoid cannabinoid receptor conditioned place aversion cyclooxygenase-2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	astrocyte cannabinoid cannabinoid receptor conditioned place aversion cyclooxygenase-2 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jin Cong Kangrong Lu Wenjie Zou Ziming Li Zhipeng Guo Xiangzhen Tong Jiawei Zheng Jiawei Zheng Jianping Zhu Shuji Li Wangming Zhang Yanwu Guo Tian-Ming Gao Tian-Ming Gao Rongqing Chen Rongqing Chen Rongqing Chen Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
description	Cannabinoids (CBs), such as phytocannabinoids, synthetic CBs, and endogenous CBs, can be neuroprotective, rewarding, or aversive. The aversive effects of CBs may hinder their medical and recreational applications. It is unknown which type of CB receptors mediates the direct aversive effects of synthetic CB CP 55,940 which is an analog of Δ9-tetrahydrocannabinol, the major psychoactive component of marijuana. In this study, we address this question by taking the advantage of systematic type 1 CB receptor (CB1R) knockout mice and conditional reinstatement of this receptor only in astrocytes. We show that CP 55,940 at a concentration of 1 mg/kg induces conditioned place aversion (CPA) and the CPA effect of CP 55,940 is mediated by the astroglial CB1Rs. Inhibiting cyclooxygenase-2 (COX-2) eliminates CP 55,940-induced CPA in mice that only express CB1Rs in astrocytes. These findings conclude that CPA effect of CP 55,940 is mediated by the astroglial CB1Rs through COX-2 signaling, suggesting that selective COX-2 inhibition or precise isolation of astroglial CB1R activity may be the strategy for treating aversive response of medical and recreational administrations of marijuana.
format	article
author	Jin Cong Kangrong Lu Wenjie Zou Ziming Li Zhipeng Guo Xiangzhen Tong Jiawei Zheng Jiawei Zheng Jianping Zhu Shuji Li Wangming Zhang Yanwu Guo Tian-Ming Gao Tian-Ming Gao Rongqing Chen Rongqing Chen Rongqing Chen
author_facet	Jin Cong Kangrong Lu Wenjie Zou Ziming Li Zhipeng Guo Xiangzhen Tong Jiawei Zheng Jiawei Zheng Jianping Zhu Shuji Li Wangming Zhang Yanwu Guo Tian-Ming Gao Tian-Ming Gao Rongqing Chen Rongqing Chen Rongqing Chen
author_sort	Jin Cong
title	Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
title_short	Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
title_full	Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
title_fullStr	Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
title_full_unstemmed	Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice
title_sort	astroglial cb1 cannabinoid receptors mediate cp 55,940-induced conditioned place aversion through cyclooxygenase-2 signaling in mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/929ee7a5809e4edc926b2280e71e6705
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Astroglial CB1 Cannabinoid Receptors Mediate CP 55,940-Induced Conditioned Place Aversion Through Cyclooxygenase-2 Signaling in Mice

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