Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization

Using a chiral catalyst to override the innate stereochemical outcome of a diastereoselective process is a challenging task. Here, the authors use theory and experiment to develop a cycloisomerization where the enantioselectivity is driven by the electronic nature of the ligand regardless of the rea...

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Autores principales:	R. N. Straker, Q. Peng, A. Mekareeya, R. S. Paton, E. A. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/929fe8d744644847bf167208cfbb6c28
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spelling	oai:doaj.org-article:929fe8d744644847bf167208cfbb6c282021-12-02T16:56:45ZComputational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization10.1038/ncomms101092041-1723https://doaj.org/article/929fe8d744644847bf167208cfbb6c282016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10109https://doaj.org/toc/2041-1723Using a chiral catalyst to override the innate stereochemical outcome of a diastereoselective process is a challenging task. Here, the authors use theory and experiment to develop a cycloisomerization where the enantioselectivity is driven by the electronic nature of the ligand regardless of the reaction's inherent diastereoselectivity.R. N. StrakerQ. PengA. MekareeyaR. S. PatonE. A. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q R. N. Straker Q. Peng A. Mekareeya R. S. Paton E. A. Anderson Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
description	Using a chiral catalyst to override the innate stereochemical outcome of a diastereoselective process is a challenging task. Here, the authors use theory and experiment to develop a cycloisomerization where the enantioselectivity is driven by the electronic nature of the ligand regardless of the reaction's inherent diastereoselectivity.
format	article
author	R. N. Straker Q. Peng A. Mekareeya R. S. Paton E. A. Anderson
author_facet	R. N. Straker Q. Peng A. Mekareeya R. S. Paton E. A. Anderson
author_sort	R. N. Straker
title	Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
title_short	Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
title_full	Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
title_fullStr	Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
title_full_unstemmed	Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
title_sort	computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/929fe8d744644847bf167208cfbb6c28
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Computational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization

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