Early constipation predicts faster dementia onset in Parkinson’s disease

Abstract Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of incident community-bas...

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Autores principales:	M. Camacho, A. D. Macleod, J. Maple-Grødem, J. R. Evans, D. P. Breen, G. Cummins, R. S. Wijeyekoon, J. C. Greenland, G. Alves, O. B. Tysnes, R. A. Lawson, R. A. Barker, C. H. Williams-Gray
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/92a07266a7b04b56960eca4a35a3c9bb
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spelling	oai:doaj.org-article:92a07266a7b04b56960eca4a35a3c9bb2021-12-02T15:49:36ZEarly constipation predicts faster dementia onset in Parkinson’s disease10.1038/s41531-021-00191-w2373-8057https://doaj.org/article/92a07266a7b04b56960eca4a35a3c9bb2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00191-whttps://doaj.org/toc/2373-8057Abstract Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (n = 313, 67.3%), minor (n = 97, 20.9%) and major (n = 55, 11.8%). Clinical progression to all three outcomes was more rapid in those with more severe constipation at baseline (Kaplan–Meier survival analysis). Cox regression analysis, adjusting for relevant confounders, confirmed a significant relationship between constipation severity and progression to dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.M. CamachoA. D. MacleodJ. Maple-GrødemJ. R. EvansD. P. BreenG. CumminsR. S. WijeyekoonJ. C. GreenlandG. AlvesO. B. TysnesR. A. LawsonR. A. BarkerC. H. Williams-GrayNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 M. Camacho A. D. Macleod J. Maple-Grødem J. R. Evans D. P. Breen G. Cummins R. S. Wijeyekoon J. C. Greenland G. Alves O. B. Tysnes R. A. Lawson R. A. Barker C. H. Williams-Gray Early constipation predicts faster dementia onset in Parkinson’s disease
description	Abstract Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson’s Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (n = 313, 67.3%), minor (n = 97, 20.9%) and major (n = 55, 11.8%). Clinical progression to all three outcomes was more rapid in those with more severe constipation at baseline (Kaplan–Meier survival analysis). Cox regression analysis, adjusting for relevant confounders, confirmed a significant relationship between constipation severity and progression to dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.
format	article
author	M. Camacho A. D. Macleod J. Maple-Grødem J. R. Evans D. P. Breen G. Cummins R. S. Wijeyekoon J. C. Greenland G. Alves O. B. Tysnes R. A. Lawson R. A. Barker C. H. Williams-Gray
author_facet	M. Camacho A. D. Macleod J. Maple-Grødem J. R. Evans D. P. Breen G. Cummins R. S. Wijeyekoon J. C. Greenland G. Alves O. B. Tysnes R. A. Lawson R. A. Barker C. H. Williams-Gray
author_sort	M. Camacho
title	Early constipation predicts faster dementia onset in Parkinson’s disease
title_short	Early constipation predicts faster dementia onset in Parkinson’s disease
title_full	Early constipation predicts faster dementia onset in Parkinson’s disease
title_fullStr	Early constipation predicts faster dementia onset in Parkinson’s disease
title_full_unstemmed	Early constipation predicts faster dementia onset in Parkinson’s disease
title_sort	early constipation predicts faster dementia onset in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92a07266a7b04b56960eca4a35a3c9bb
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Early constipation predicts faster dementia onset in Parkinson’s disease

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