Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3

Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous fi...

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Autores principales:	Soren Alexandersen, Tiffanie M. Nelson, Jason Hodge, Julian Druce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92a1136b8df64992b009fa8896f1031d
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spelling	oai:doaj.org-article:92a1136b8df64992b009fa8896f1031d2021-12-02T11:40:13ZEvolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 310.1038/s41598-017-04145-22045-2322https://doaj.org/article/92a1136b8df64992b009fa8896f1031d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04145-2https://doaj.org/toc/2045-2322Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.Soren AlexandersenTiffanie M. NelsonJason HodgeJulian DruceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Soren Alexandersen Tiffanie M. Nelson Jason Hodge Julian Druce Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
description	Abstract We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
format	article
author	Soren Alexandersen Tiffanie M. Nelson Jason Hodge Julian Druce
author_facet	Soren Alexandersen Tiffanie M. Nelson Jason Hodge Julian Druce
author_sort	Soren Alexandersen
title	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
title_short	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
title_full	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
title_fullStr	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
title_full_unstemmed	Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
title_sort	evolutionary and network analysis of virus sequences from infants infected with an australian recombinant strain of human parechovirus type 3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92a1136b8df64992b009fa8896f1031d
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Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3

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