Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.

Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still...

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Autores principales:	Thomas Beneteau, Christian Selinger, Mircea T Sofonea, Samuel Alizon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/92a308c82fe04712a9b319a4c1ca9944
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spelling	oai:doaj.org-article:92a308c82fe04712a9b319a4c1ca99442021-12-02T19:57:50ZEpisome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.1553-734X1553-735810.1371/journal.pcbi.1009352https://doaj.org/article/92a308c82fe04712a9b319a4c1ca99442021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009352https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.Thomas BeneteauChristian SelingerMircea T SofoneaSamuel AlizonPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 9, p e1009352 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
description	Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.
format	article
author	Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon
author_facet	Thomas Beneteau Christian Selinger Mircea T Sofonea Samuel Alizon
author_sort	Thomas Beneteau
title	Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
title_short	Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
title_full	Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
title_fullStr	Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
title_full_unstemmed	Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
title_sort	episome partitioning and symmetric cell divisions: quantifying the role of random events in the persistence of hpv infections.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/92a308c82fe04712a9b319a4c1ca9944
work_keys_str_mv	AT thomasbeneteau episomepartitioningandsymmetriccelldivisionsquantifyingtheroleofrandomeventsinthepersistenceofhpvinfections AT christianselinger episomepartitioningandsymmetriccelldivisionsquantifyingtheroleofrandomeventsinthepersistenceofhpvinfections AT mirceatsofonea episomepartitioningandsymmetriccelldivisionsquantifyingtheroleofrandomeventsinthepersistenceofhpvinfections AT samuelalizon episomepartitioningandsymmetriccelldivisionsquantifyingtheroleofrandomeventsinthepersistenceofhpvinfections
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Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.

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