REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS

The paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4...

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Autores principales:	N. R. Telesmanich, M. A. Konovalchik, Z. I. Mikashinovich, E. G. Krivolapova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	specific ige ige antibodies blood group (ab0) antigenic determinants diabetes carbohydrate metabolism disorders insulin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/92a4349411a54d34a5f6efa0c373778b
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spelling	oai:doaj.org-article:92a4349411a54d34a5f6efa0c373778b2021-11-18T08:03:47ZREAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS1563-06252313-741X10.15789/1563-0625-2018-4-589-596https://doaj.org/article/92a4349411a54d34a5f6efa0c373778b2018-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1567https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4 mmol/l. Such values are characteristic to the patients with A (II) and B (III) blood groups with normal glucose levels. Among subjects with B (III) blood group showing decreased glucose values (< 4 mmol/L), the lowest insulin induction (0.85±0.05 mkE/ml) was observed, and the IgE production to insulin increased 80-fold, reaching 113.0±56.0 kE/L. At the first ("borderline") stage of carbohydrate metabolism disorders (glucose levels 6.0 to 7.6 mmol/L), the insulin production is increased 3-fold in 0 (I) and A (II) blood groups, whereas insulin levels in persons with B(III) blood group are near-normal (12.3±3.7), and IgE antibodies to insulin show lowest levels (27.2±9.08 kE/L), thus being 5 times lower when compared to the persons with B (III) blood group. However, carriers of all three group antigens and patients with expressed type 2 diabetes respond to increased glucose and insulin levels in blood by decreased production of specific IgE antibodies to insulin.N. R. TelesmanichM. A. KonovalchikZ. I. MikashinovichE. G. KrivolapovaSPb RAACIarticlespecific igeigeantibodiesblood group (ab0)antigenic determinantsdiabetescarbohydrate metabolism disordersinsulinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 4, Pp 589-596 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	specific ige ige antibodies blood group (ab0) antigenic determinants diabetes carbohydrate metabolism disorders insulin Immunologic diseases. Allergy RC581-607
spellingShingle	specific ige ige antibodies blood group (ab0) antigenic determinants diabetes carbohydrate metabolism disorders insulin Immunologic diseases. Allergy RC581-607 N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
description	The paper presents evidence that the individuals with different blood groups and glucose levels exhibit individual IgE reagin responses to insulin. Thus, the persons with 0 (I) blood group showed the highest values of anti-insulin-specific IgE (124.83±67.9 kE/L) when their glucose level was under 4 mmol/l. Such values are characteristic to the patients with A (II) and B (III) blood groups with normal glucose levels. Among subjects with B (III) blood group showing decreased glucose values (< 4 mmol/L), the lowest insulin induction (0.85±0.05 mkE/ml) was observed, and the IgE production to insulin increased 80-fold, reaching 113.0±56.0 kE/L. At the first ("borderline") stage of carbohydrate metabolism disorders (glucose levels 6.0 to 7.6 mmol/L), the insulin production is increased 3-fold in 0 (I) and A (II) blood groups, whereas insulin levels in persons with B(III) blood group are near-normal (12.3±3.7), and IgE antibodies to insulin show lowest levels (27.2±9.08 kE/L), thus being 5 times lower when compared to the persons with B (III) blood group. However, carriers of all three group antigens and patients with expressed type 2 diabetes respond to increased glucose and insulin levels in blood by decreased production of specific IgE antibodies to insulin.
format	article
author	N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova
author_facet	N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova
author_sort	N. R. Telesmanich
title	REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
title_short	REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
title_full	REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
title_fullStr	REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
title_full_unstemmed	REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS
title_sort	reagin-specific response to insulin level in carbohydrate metabolism disorders is dependent on the blood group abo antigenic determinants
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/92a4349411a54d34a5f6efa0c373778b
work_keys_str_mv	AT nrtelesmanich reaginspecificresponsetoinsulinlevelincarbohydratemetabolismdisordersisdependentonthebloodgroupaboantigenicdeterminants AT makonovalchik reaginspecificresponsetoinsulinlevelincarbohydratemetabolismdisordersisdependentonthebloodgroupaboantigenicdeterminants AT zimikashinovich reaginspecificresponsetoinsulinlevelincarbohydratemetabolismdisordersisdependentonthebloodgroupaboantigenicdeterminants AT egkrivolapova reaginspecificresponsetoinsulinlevelincarbohydratemetabolismdisordersisdependentonthebloodgroupaboantigenicdeterminants
_version_	1718422366245093376

REAGIN-SPECIFIC RESPONSE TO INSULIN LEVEL IN CARBOHYDRATE METABOLISM DISORDERS IS DEPENDENT ON THE BLOOD GROUP ABO ANTIGENIC DETERMINANTS

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