Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes

A fraction of mammalian CTCF binding sites fall within transposable elements (TEs) but their contribution to the evolution of 3D chromatin structure is unknown. Here the authors investigate the effect of TE-driven CTCF binding site expansions on chromatin looping in humans and mice, and provide evid...

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Autores principales:	Adam G. Diehl, Ningxin Ouyang, Alan P. Boyle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92a43e8e744343bfb98662cec180788a
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spelling	oai:doaj.org-article:92a43e8e744343bfb98662cec180788a2021-12-02T14:42:32ZTransposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes10.1038/s41467-020-15520-52041-1723https://doaj.org/article/92a43e8e744343bfb98662cec180788a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15520-5https://doaj.org/toc/2041-1723A fraction of mammalian CTCF binding sites fall within transposable elements (TEs) but their contribution to the evolution of 3D chromatin structure is unknown. Here the authors investigate the effect of TE-driven CTCF binding site expansions on chromatin looping in humans and mice, and provide evidence that TEs contribute to cell-specific and species-specific chromatin looping diversity and variable gene regulation in mammalian genomes.Adam G. DiehlNingxin OuyangAlan P. BoyleNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam G. Diehl Ningxin Ouyang Alan P. Boyle Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
description	A fraction of mammalian CTCF binding sites fall within transposable elements (TEs) but their contribution to the evolution of 3D chromatin structure is unknown. Here the authors investigate the effect of TE-driven CTCF binding site expansions on chromatin looping in humans and mice, and provide evidence that TEs contribute to cell-specific and species-specific chromatin looping diversity and variable gene regulation in mammalian genomes.
format	article
author	Adam G. Diehl Ningxin Ouyang Alan P. Boyle
author_facet	Adam G. Diehl Ningxin Ouyang Alan P. Boyle
author_sort	Adam G. Diehl
title	Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
title_short	Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
title_full	Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
title_fullStr	Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
title_full_unstemmed	Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
title_sort	transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/92a43e8e744343bfb98662cec180788a
work_keys_str_mv	AT adamgdiehl transposableelementscontributetocellandspeciesspecificchromatinloopingandgeneregulationinmammaliangenomes AT ningxinouyang transposableelementscontributetocellandspeciesspecificchromatinloopingandgeneregulationinmammaliangenomes AT alanpboyle transposableelementscontributetocellandspeciesspecificchromatinloopingandgeneregulationinmammaliangenomes
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Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes

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