X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

Defensins are cationic antimicrobial peptides that permeabilize membranes of pathogens presumably via the assembly of defensin–lipid oligomers. Here authors provide evidence for this by solving the crystal structure of a plant defensin in an oligomeric state with phospholipids.

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Autores principales:	Michael Järvå, Fung T. Lay, Thanh Kha Phan, Cassandra Humble, Ivan K. H. Poon, Mark R. Bleackley, Marilyn A. Anderson, Mark D. Hulett, Marc Kvansakul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92a541026fb04b6bafa9a12c66ec4740
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spelling	oai:doaj.org-article:92a541026fb04b6bafa9a12c66ec47402021-12-02T16:56:38ZX-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex10.1038/s41467-018-04434-y2041-1723https://doaj.org/article/92a541026fb04b6bafa9a12c66ec47402018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04434-yhttps://doaj.org/toc/2041-1723Defensins are cationic antimicrobial peptides that permeabilize membranes of pathogens presumably via the assembly of defensin–lipid oligomers. Here authors provide evidence for this by solving the crystal structure of a plant defensin in an oligomeric state with phospholipids.Michael JärvåFung T. LayThanh Kha PhanCassandra HumbleIvan K. H. PoonMark R. BleackleyMarilyn A. AndersonMark D. HulettMarc KvansakulNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Järvå Fung T. Lay Thanh Kha Phan Cassandra Humble Ivan K. H. Poon Mark R. Bleackley Marilyn A. Anderson Mark D. Hulett Marc Kvansakul X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
description	Defensins are cationic antimicrobial peptides that permeabilize membranes of pathogens presumably via the assembly of defensin–lipid oligomers. Here authors provide evidence for this by solving the crystal structure of a plant defensin in an oligomeric state with phospholipids.
format	article
author	Michael Järvå Fung T. Lay Thanh Kha Phan Cassandra Humble Ivan K. H. Poon Mark R. Bleackley Marilyn A. Anderson Mark D. Hulett Marc Kvansakul
author_facet	Michael Järvå Fung T. Lay Thanh Kha Phan Cassandra Humble Ivan K. H. Poon Mark R. Bleackley Marilyn A. Anderson Mark D. Hulett Marc Kvansakul
author_sort	Michael Järvå
title	X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
title_short	X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
title_full	X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
title_fullStr	X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
title_full_unstemmed	X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
title_sort	x-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/92a541026fb04b6bafa9a12c66ec4740
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X-ray structure of a carpet-like antimicrobial defensin–phospholipid membrane disruption complex

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