Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment
Background: Mild cognitive impairment (MCI) is considered to be a transitional state between normal aging and Alzheimer's dementia (AD). Recent studies have indicated that executive function (EF) declines during MCI. However, only a limited number of studies have investigated the neural basis o...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:92a648853a174e7cbb9542bdf53233e82021-12-01T08:20:44ZFunctional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment1663-436510.3389/fnagi.2021.710172https://doaj.org/article/92a648853a174e7cbb9542bdf53233e82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.710172/fullhttps://doaj.org/toc/1663-4365Background: Mild cognitive impairment (MCI) is considered to be a transitional state between normal aging and Alzheimer's dementia (AD). Recent studies have indicated that executive function (EF) declines during MCI. However, only a limited number of studies have investigated the neural basis of EF deficits in MCI. Herein, we investigate the changes of regional brain spontaneous activity and functional connectivity (FC) of the executive control network (ECN) between high EF and low EF groups.Methods: According to EF composite score (ADNI-EF) from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we divided MCI into two groups, including the MCI-highEF group and MCI-lowEF group. Resting-state functional MRI was utilized to investigate the fractional amplitude of low-frequency fluctuation (fALFF) and ECN functional connectivity across 23 healthy controls (HC), 11 MCI-highEF, and 14 MCI-lowEF participants. Moreover, a partial correlation analysis was carried out to examine the relationship between altered fALFF or connectivity of the ECN and the ADNI-EF.Results: Compared to HC, the MCI-highEF participants demonstrated increased fALFF in the left superior temporal gyrus (STG), as well as decreased fALFF in the right precentral gyrus, right postcentral gyrus, and left middle frontal gyrus (MFG). The MCI-lowEF participants demonstrated increased fALFF in the cerebellar vermis and decreased fALFF in the left MFG. Additionally, compared to HC, the MCI-highEF participants indicated no significant difference in connectivity of the ECN. Furthermore, the MCI-lowEF participants showed increased ECN FC in the left cuneus and left MFG, as well as decreased ECN functional connectivity in the right parahippocampal gyrus (PHG). Notably, the altered fALFF in the left MFG was positively correlated to ADNI-EF, while the altered fALFF in cerebellar vermis is negatively correlated with ADNI-EF across the two MCI groups and the HC group. Altered ECN functional connectivity in the right PHG is negatively correlated to ADNI-EF, while altered ECN functional connectivity in the left cuneus is negatively correlated to ADNI-EF across the three groups.Conclusions: Our current study demonstrates the presence of different patterns of regional brain spontaneous activity and ECN FC in the MCI-highEF group and MCI-lowEF group. Furthermore, the ECN FC of the MCI-highEF group was not disrupted, which may contribute to retained EF in MCI.Wan LiuLi LiuXinxin ChengHonglin GeHonglin GeGuanjie HuGuanjie HuChen XueChen XueWenzhang QiWenzhang QiWenwen XuShanshan ChenRun GaoJiang RaoJiu ChenJiu ChenFrontiers Media S.A.articlemild cognitive impairmentexecutive functionexecutive control networkfunctional connectivityfractional amplitude of low-frequency fluctuationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021) |
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| topic |
mild cognitive impairment executive function executive control network functional connectivity fractional amplitude of low-frequency fluctuation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
| spellingShingle |
mild cognitive impairment executive function executive control network functional connectivity fractional amplitude of low-frequency fluctuation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Wan Liu Li Liu Xinxin Cheng Honglin Ge Honglin Ge Guanjie Hu Guanjie Hu Chen Xue Chen Xue Wenzhang Qi Wenzhang Qi Wenwen Xu Shanshan Chen Run Gao Jiang Rao Jiu Chen Jiu Chen Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| description |
Background: Mild cognitive impairment (MCI) is considered to be a transitional state between normal aging and Alzheimer's dementia (AD). Recent studies have indicated that executive function (EF) declines during MCI. However, only a limited number of studies have investigated the neural basis of EF deficits in MCI. Herein, we investigate the changes of regional brain spontaneous activity and functional connectivity (FC) of the executive control network (ECN) between high EF and low EF groups.Methods: According to EF composite score (ADNI-EF) from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we divided MCI into two groups, including the MCI-highEF group and MCI-lowEF group. Resting-state functional MRI was utilized to investigate the fractional amplitude of low-frequency fluctuation (fALFF) and ECN functional connectivity across 23 healthy controls (HC), 11 MCI-highEF, and 14 MCI-lowEF participants. Moreover, a partial correlation analysis was carried out to examine the relationship between altered fALFF or connectivity of the ECN and the ADNI-EF.Results: Compared to HC, the MCI-highEF participants demonstrated increased fALFF in the left superior temporal gyrus (STG), as well as decreased fALFF in the right precentral gyrus, right postcentral gyrus, and left middle frontal gyrus (MFG). The MCI-lowEF participants demonstrated increased fALFF in the cerebellar vermis and decreased fALFF in the left MFG. Additionally, compared to HC, the MCI-highEF participants indicated no significant difference in connectivity of the ECN. Furthermore, the MCI-lowEF participants showed increased ECN FC in the left cuneus and left MFG, as well as decreased ECN functional connectivity in the right parahippocampal gyrus (PHG). Notably, the altered fALFF in the left MFG was positively correlated to ADNI-EF, while the altered fALFF in cerebellar vermis is negatively correlated with ADNI-EF across the two MCI groups and the HC group. Altered ECN functional connectivity in the right PHG is negatively correlated to ADNI-EF, while altered ECN functional connectivity in the left cuneus is negatively correlated to ADNI-EF across the three groups.Conclusions: Our current study demonstrates the presence of different patterns of regional brain spontaneous activity and ECN FC in the MCI-highEF group and MCI-lowEF group. Furthermore, the ECN FC of the MCI-highEF group was not disrupted, which may contribute to retained EF in MCI. |
| format |
article |
| author |
Wan Liu Li Liu Xinxin Cheng Honglin Ge Honglin Ge Guanjie Hu Guanjie Hu Chen Xue Chen Xue Wenzhang Qi Wenzhang Qi Wenwen Xu Shanshan Chen Run Gao Jiang Rao Jiu Chen Jiu Chen |
| author_facet |
Wan Liu Li Liu Xinxin Cheng Honglin Ge Honglin Ge Guanjie Hu Guanjie Hu Chen Xue Chen Xue Wenzhang Qi Wenzhang Qi Wenwen Xu Shanshan Chen Run Gao Jiang Rao Jiu Chen Jiu Chen |
| author_sort |
Wan Liu |
| title |
Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| title_short |
Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| title_full |
Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| title_fullStr |
Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| title_full_unstemmed |
Functional Integrity of Executive Control Network Contributed to Retained Executive Abilities in Mild Cognitive Impairment |
| title_sort |
functional integrity of executive control network contributed to retained executive abilities in mild cognitive impairment |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/92a648853a174e7cbb9542bdf53233e8 |
| work_keys_str_mv |
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