Dynamic mechanisms of neocortical focal seizure onset.

Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathemati...

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Autores principales:	Yujiang Wang, Marc Goodfellow, Peter Neal Taylor, Gerold Baier
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/92a67c48c4bb44feb8f7c390d8424442
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spelling	oai:doaj.org-article:92a67c48c4bb44feb8f7c390d84244422021-11-25T05:40:50ZDynamic mechanisms of neocortical focal seizure onset.1553-734X1553-735810.1371/journal.pcbi.1003787https://doaj.org/article/92a67c48c4bb44feb8f7c390d84244422014-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25122455/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathematical model of cortical electric activity with realistic mesoscopic connectivity. Relating the model dynamics to experimental and clinical findings leads us to propose three classes of dynamical mechanisms for the onset of focal seizures in a unified framework. These three classes are: (i) globally induced focal seizures; (ii) globally supported focal seizures; (iii) locally induced focal seizures. Using model simulations we illustrate these onset mechanisms and show how the three classes can be distinguished. Specifically, we find that although all focal seizures typically appear to arise from localised tissue, the mechanisms of onset could be due to either localised processes or processes on a larger spatial scale. We conclude that although focal seizures might have different patient-specific aetiologies and electrographic signatures, our model suggests that dynamically they can still be classified in a clinically useful way. Additionally, this novel classification according to the dynamical mechanisms is able to resolve some of the previously conflicting experimental and clinical findings.Yujiang WangMarc GoodfellowPeter Neal TaylorGerold BaierPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 8, p e1003787 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yujiang Wang Marc Goodfellow Peter Neal Taylor Gerold Baier Dynamic mechanisms of neocortical focal seizure onset.
description	Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathematical model of cortical electric activity with realistic mesoscopic connectivity. Relating the model dynamics to experimental and clinical findings leads us to propose three classes of dynamical mechanisms for the onset of focal seizures in a unified framework. These three classes are: (i) globally induced focal seizures; (ii) globally supported focal seizures; (iii) locally induced focal seizures. Using model simulations we illustrate these onset mechanisms and show how the three classes can be distinguished. Specifically, we find that although all focal seizures typically appear to arise from localised tissue, the mechanisms of onset could be due to either localised processes or processes on a larger spatial scale. We conclude that although focal seizures might have different patient-specific aetiologies and electrographic signatures, our model suggests that dynamically they can still be classified in a clinically useful way. Additionally, this novel classification according to the dynamical mechanisms is able to resolve some of the previously conflicting experimental and clinical findings.
format	article
author	Yujiang Wang Marc Goodfellow Peter Neal Taylor Gerold Baier
author_facet	Yujiang Wang Marc Goodfellow Peter Neal Taylor Gerold Baier
author_sort	Yujiang Wang
title	Dynamic mechanisms of neocortical focal seizure onset.
title_short	Dynamic mechanisms of neocortical focal seizure onset.
title_full	Dynamic mechanisms of neocortical focal seizure onset.
title_fullStr	Dynamic mechanisms of neocortical focal seizure onset.
title_full_unstemmed	Dynamic mechanisms of neocortical focal seizure onset.
title_sort	dynamic mechanisms of neocortical focal seizure onset.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/92a67c48c4bb44feb8f7c390d8424442
work_keys_str_mv	AT yujiangwang dynamicmechanismsofneocorticalfocalseizureonset AT marcgoodfellow dynamicmechanismsofneocorticalfocalseizureonset AT peternealtaylor dynamicmechanismsofneocorticalfocalseizureonset AT geroldbaier dynamicmechanismsofneocorticalfocalseizureonset
_version_	1718414530775613440

Dynamic mechanisms of neocortical focal seizure onset.

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