Structural basis for UFM1 transfer from UBA5 to UFC1
Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process.
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Nature Portfolio
2021
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oai:doaj.org-article:92a7bec4aca04541b5ce9c87607504cd2021-12-02T18:51:37ZStructural basis for UFM1 transfer from UBA5 to UFC110.1038/s41467-021-25994-62041-1723https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25994-6https://doaj.org/toc/2041-1723Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process.Manoj KumarPrasanth PadalaJamal FahoumFouad HassounaTomer TsabanGuy ZoltsmanSayanika BanerjeeEinav Cohen-KfirMoshe DessauRina RosenzweigMichail N. IsupovOra Schueler-FurmanReuven WienerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Manoj Kumar Prasanth Padala Jamal Fahoum Fouad Hassouna Tomer Tsaban Guy Zoltsman Sayanika Banerjee Einav Cohen-Kfir Moshe Dessau Rina Rosenzweig Michail N. Isupov Ora Schueler-Furman Reuven Wiener Structural basis for UFM1 transfer from UBA5 to UFC1 |
| description |
Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process. |
| format |
article |
| author |
Manoj Kumar Prasanth Padala Jamal Fahoum Fouad Hassouna Tomer Tsaban Guy Zoltsman Sayanika Banerjee Einav Cohen-Kfir Moshe Dessau Rina Rosenzweig Michail N. Isupov Ora Schueler-Furman Reuven Wiener |
| author_facet |
Manoj Kumar Prasanth Padala Jamal Fahoum Fouad Hassouna Tomer Tsaban Guy Zoltsman Sayanika Banerjee Einav Cohen-Kfir Moshe Dessau Rina Rosenzweig Michail N. Isupov Ora Schueler-Furman Reuven Wiener |
| author_sort |
Manoj Kumar |
| title |
Structural basis for UFM1 transfer from UBA5 to UFC1 |
| title_short |
Structural basis for UFM1 transfer from UBA5 to UFC1 |
| title_full |
Structural basis for UFM1 transfer from UBA5 to UFC1 |
| title_fullStr |
Structural basis for UFM1 transfer from UBA5 to UFC1 |
| title_full_unstemmed |
Structural basis for UFM1 transfer from UBA5 to UFC1 |
| title_sort |
structural basis for ufm1 transfer from uba5 to ufc1 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd |
| work_keys_str_mv |
AT manojkumar structuralbasisforufm1transferfromuba5toufc1 AT prasanthpadala structuralbasisforufm1transferfromuba5toufc1 AT jamalfahoum structuralbasisforufm1transferfromuba5toufc1 AT fouadhassouna structuralbasisforufm1transferfromuba5toufc1 AT tomertsaban structuralbasisforufm1transferfromuba5toufc1 AT guyzoltsman structuralbasisforufm1transferfromuba5toufc1 AT sayanikabanerjee structuralbasisforufm1transferfromuba5toufc1 AT einavcohenkfir structuralbasisforufm1transferfromuba5toufc1 AT moshedessau structuralbasisforufm1transferfromuba5toufc1 AT rinarosenzweig structuralbasisforufm1transferfromuba5toufc1 AT michailnisupov structuralbasisforufm1transferfromuba5toufc1 AT oraschuelerfurman structuralbasisforufm1transferfromuba5toufc1 AT reuvenwiener structuralbasisforufm1transferfromuba5toufc1 |
| _version_ |
1718377397168898048 |