Structural basis for UFM1 transfer from UBA5 to UFC1

Structural basis for UFM1 transfer from UBA5 to UFC1

Ufmylation is a well-established ubiquitin-like protein modification, but its mechanism is largely unclear. Here, the authors present a crystal structure of the ufmylation-specific E1-E2 complex, revealing differences to the ubiquitination machinery and mechanistic details of the ufmylation process.

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Bibliographic Details
Main Authors: Manoj Kumar, Prasanth Padala, Jamal Fahoum, Fouad Hassouna, Tomer Tsaban, Guy Zoltsman, Sayanika Banerjee, Einav Cohen-Kfir, Moshe Dessau, Rina Rosenzweig, Michail N. Isupov, Ora Schueler-Furman, Reuven Wiener
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd
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Internet

https://doaj.org/article/92a7bec4aca04541b5ce9c87607504cd

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