R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, inclu...

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Autores principales:	Christine Harnack, Hilmar Berger, Agne Antanaviciute, Ramon Vidal, Sascha Sauer, Alison Simmons, Thomas F. Meyer, Michael Sigal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92a90fca25a047f5b37a3718152ed773
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spelling	oai:doaj.org-article:92a90fca25a047f5b37a3718152ed7732021-12-02T16:58:03ZR-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon10.1038/s41467-019-12349-52041-1723https://doaj.org/article/92a90fca25a047f5b37a3718152ed7732019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12349-5https://doaj.org/toc/2041-1723Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, including Krt20+ enterocytes.Christine HarnackHilmar BergerAgne AntanaviciuteRamon VidalSascha SauerAlison SimmonsThomas F. MeyerMichael SigalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christine Harnack Hilmar Berger Agne Antanaviciute Ramon Vidal Sascha Sauer Alison Simmons Thomas F. Meyer Michael Sigal R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
description	Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, including Krt20+ enterocytes.
format	article
author	Christine Harnack Hilmar Berger Agne Antanaviciute Ramon Vidal Sascha Sauer Alison Simmons Thomas F. Meyer Michael Sigal
author_facet	Christine Harnack Hilmar Berger Agne Antanaviciute Ramon Vidal Sascha Sauer Alison Simmons Thomas F. Meyer Michael Sigal
author_sort	Christine Harnack
title	R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
title_short	R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
title_full	R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
title_fullStr	R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
title_full_unstemmed	R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
title_sort	r-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/92a90fca25a047f5b37a3718152ed773
work_keys_str_mv	AT christineharnack rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT hilmarberger rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT agneantanaviciute rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT ramonvidal rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT saschasauer rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT alisonsimmons rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT thomasfmeyer rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon AT michaelsigal rspondin3promotesstemcellrecoveryandepithelialregenerationinthecolon
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R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

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