R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, inclu...

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Autores principales: Christine Harnack, Hilmar Berger, Agne Antanaviciute, Ramon Vidal, Sascha Sauer, Alison Simmons, Thomas F. Meyer, Michael Sigal
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/92a90fca25a047f5b37a3718152ed773
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