Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B

Abstract Host immune response and chronic inflammation associated with chronic hepatitis B virus (HBV) infection play a key role in the pathogenesis of liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). We sampled 175 HCC, 117 cirrhotic and 165 non-cirrhotic controls from a prospec...

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Autores principales:	Ilona Argirion, Ruth M. Pfeiffer, Tram Kim Lam, Thomas R. O’Brien, Kelly Yu, Katherine A. McGlynn, Jessica L. Petrick, Ligia Pinto, Chien-Jen Chen, Mei-Hsuan Lee, Allan Hildesheim, Hwai-I Yang, Jill Koshiol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92ab3796a54c439597e971589eac9458
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spelling	oai:doaj.org-article:92ab3796a54c439597e971589eac94582021-11-21T12:19:40ZAssociation between immunologic markers and cirrhosis in individuals with chronic hepatitis B10.1038/s41598-021-00455-82045-2322https://doaj.org/article/92ab3796a54c439597e971589eac94582021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00455-8https://doaj.org/toc/2045-2322Abstract Host immune response and chronic inflammation associated with chronic hepatitis B virus (HBV) infection play a key role in the pathogenesis of liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). We sampled 175 HCC, 117 cirrhotic and 165 non-cirrhotic controls from a prospective cohort study of chronically HBV-infected individuals. Multivariable polytomous logistic regression and canonical discriminant analysis (CDA) were used to compare baseline plasma levels for 102 markers in individuals who developed cirrhosis vs. controls and those who developed HCC vs. cirrhosis. Leave-one-out cross validation was used to generate receiver operating characteristic curves to compare the predictive ability of marker groups. After multivariable adjustment, HGF (Q4v1OR: 3.74; p-trend = 0.0001), SLAMF1 (Q4v1OR: 4.07; p-trend = 0.0001), CSF1 (Q4v1OR: 3.00; p-trend = 0.002), uPA (Q4v1OR: 3.36; p-trend = 0.002), IL-8 (Q4v1OR: 2.83; p-trend = 0.004), and OPG (Q4v1OR: 2.44; p-trend = 0.005) were all found to be associated with cirrhosis development compared to controls; these markers predicted cirrhosis with 69% accuracy. CDA analysis identified a nine marker model capable of predicting cirrhosis development with 79% accuracy. No markers were significantly different between HCC and cirrhotic participants. In this study, we assessed immunologic markers in relation to liver disease in chronically-HBV infected individuals. While validation in required, these findings highlight the importance of immunologic processes in HBV-related cirrhosis.Ilona ArgirionRuth M. PfeifferTram Kim LamThomas R. O’BrienKelly YuKatherine A. McGlynnJessica L. PetrickLigia PintoChien-Jen ChenMei-Hsuan LeeAllan HildesheimHwai-I YangJill KoshiolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ilona Argirion Ruth M. Pfeiffer Tram Kim Lam Thomas R. O’Brien Kelly Yu Katherine A. McGlynn Jessica L. Petrick Ligia Pinto Chien-Jen Chen Mei-Hsuan Lee Allan Hildesheim Hwai-I Yang Jill Koshiol Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
description	Abstract Host immune response and chronic inflammation associated with chronic hepatitis B virus (HBV) infection play a key role in the pathogenesis of liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). We sampled 175 HCC, 117 cirrhotic and 165 non-cirrhotic controls from a prospective cohort study of chronically HBV-infected individuals. Multivariable polytomous logistic regression and canonical discriminant analysis (CDA) were used to compare baseline plasma levels for 102 markers in individuals who developed cirrhosis vs. controls and those who developed HCC vs. cirrhosis. Leave-one-out cross validation was used to generate receiver operating characteristic curves to compare the predictive ability of marker groups. After multivariable adjustment, HGF (Q4v1OR: 3.74; p-trend = 0.0001), SLAMF1 (Q4v1OR: 4.07; p-trend = 0.0001), CSF1 (Q4v1OR: 3.00; p-trend = 0.002), uPA (Q4v1OR: 3.36; p-trend = 0.002), IL-8 (Q4v1OR: 2.83; p-trend = 0.004), and OPG (Q4v1OR: 2.44; p-trend = 0.005) were all found to be associated with cirrhosis development compared to controls; these markers predicted cirrhosis with 69% accuracy. CDA analysis identified a nine marker model capable of predicting cirrhosis development with 79% accuracy. No markers were significantly different between HCC and cirrhotic participants. In this study, we assessed immunologic markers in relation to liver disease in chronically-HBV infected individuals. While validation in required, these findings highlight the importance of immunologic processes in HBV-related cirrhosis.
format	article
author	Ilona Argirion Ruth M. Pfeiffer Tram Kim Lam Thomas R. O’Brien Kelly Yu Katherine A. McGlynn Jessica L. Petrick Ligia Pinto Chien-Jen Chen Mei-Hsuan Lee Allan Hildesheim Hwai-I Yang Jill Koshiol
author_facet	Ilona Argirion Ruth M. Pfeiffer Tram Kim Lam Thomas R. O’Brien Kelly Yu Katherine A. McGlynn Jessica L. Petrick Ligia Pinto Chien-Jen Chen Mei-Hsuan Lee Allan Hildesheim Hwai-I Yang Jill Koshiol
author_sort	Ilona Argirion
title	Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
title_short	Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
title_full	Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
title_fullStr	Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
title_full_unstemmed	Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B
title_sort	association between immunologic markers and cirrhosis in individuals with chronic hepatitis b
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92ab3796a54c439597e971589eac9458
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Association between immunologic markers and cirrhosis in individuals with chronic hepatitis B

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