Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelli...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	La WG, Jin M, Park S, Yoon HH, Jeong GJ, Bhang SH, Park H, Char K, Kim BS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/92ad4a1fc3044522a613d72606d2d7b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92ad4a1fc3044522a613d72606d2d7b0
record_format	dspace
spelling	oai:doaj.org-article:92ad4a1fc3044522a613d72606d2d7b02021-12-02T03:53:32ZDelivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration1178-2013https://doaj.org/article/92ad4a1fc3044522a613d72606d2d7b02014-05-01T00:00:00Zhttp://www.dovepress.com/delivery-of-bone-morphogenetic-protein-2-and-substance-p-using-graphen-a16699https://doaj.org/toc/1178-2013 Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone morphogenetic protein-2 (BMP-2) and substance P (SP), and that this delivery promotes bone formation on titanium (Ti) implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs), was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance PLa WGJin MPark SYoon HHJeong GJBhang SHPark HChar KKim BSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Supplement 1, Pp 107-116 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 La WG Jin M Park S Yoon HH Jeong GJ Bhang SH Park H Char K Kim BS Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
description	Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO) can be used for the delivery of bone morphogenetic protein-2 (BMP-2) and substance P (SP), and that this delivery promotes bone formation on titanium (Ti) implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs), was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance P
format	article
author	La WG Jin M Park S Yoon HH Jeong GJ Bhang SH Park H Char K Kim BS
author_facet	La WG Jin M Park S Yoon HH Jeong GJ Bhang SH Park H Char K Kim BS
author_sort	La WG
title	Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
title_short	Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
title_full	Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
title_fullStr	Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
title_full_unstemmed	Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration
title_sort	delivery of bone morphogenetic protein-2 and substance p using graphene oxide for bone regeneration
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/92ad4a1fc3044522a613d72606d2d7b0
work_keys_str_mv	AT lawg deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT jinm deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT parks deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT yoonhh deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT jeonggj deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT bhangsh deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT parkh deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT chark deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration AT kimbs deliveryofbonemorphogeneticprotein2andsubstancepusinggrapheneoxideforboneregeneration
_version_	1718401567200116736

Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

Ejemplares similares