Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI
Li-Ting Chen,1,* Xiao-Le Fan,2,* Hai-Jun Li,1 Si Nie,1 Hong-Han Gong,1 Wei Zhang,3 Xian-Jun Zeng,1 Ping Long,4 De-Chang Peng1 1Department of Radiology, 2Department of General Surgery, 3Department of Pneumology, 4Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nan...
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Dove Medical Press
2017
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oai:doaj.org-article:92ad8384182c437f866884c4e72acf6a2021-12-02T01:12:35ZDisrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI1178-2021https://doaj.org/article/92ad8384182c437f866884c4e72acf6a2017-06-01T00:00:00Zhttps://www.dovepress.com/disrupted-small-world-brain-functional-network-topology-in-male-patien-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Li-Ting Chen,1,* Xiao-Le Fan,2,* Hai-Jun Li,1 Si Nie,1 Hong-Han Gong,1 Wei Zhang,3 Xian-Jun Zeng,1 Ping Long,4 De-Chang Peng1 1Department of Radiology, 2Department of General Surgery, 3Department of Pneumology, 4Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Purpose: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that can damage cognitive function. However, the functional network organization remains poorly understood. The aim of this study was to investigate the topological properties of OSA patients using a graph theoretical analysis.Patients and methods: A total of 30 male patients with untreated severe OSA and 25 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (MRI) examinations. Clinical and cognitive evaluations were conducted by an experienced psychologist. GRETNA (a toolbox for topological analysis of imaging connectomics) was used to construct the brain functional network and calculate the small-world properties (γ, λ, σ, Eglob, and Eloc). Relationships between these small-world properties and clinical and neuropsychological assessments were investigated in OSA patients.Results: The networks of both OSA patients and GSs exhibited efficient small-world topology over the sparsity range of 0.05–0.40. Compared with GSs, the OSA group had significantly decreased γ, but significantly increased λ and σ. The OSA group’s brain network showed significantly decreased Eglob (P<0.05) over the sparsity range of 0.09–0.15, but significantly increased Eloc over the sparsity range of 0.23–0.40. In OSA patients, γ was significantly negatively correlated with apnea–hypopnea index (AHI; r=−0.326, P=0.015) and Epworth Sleepiness Scale (ESS; r=−0.274, P=0.043), λ was significantly positively correlated with AHI (r=0.373, P=0.005) and ESS (r=0.269, P=0.047), and σ was significantly negatively correlated with AHI (r=−0.363, P=0.007) and ESS (r=−0.295, P=0.029).Conclusion: Our results suggest that the high degree of local integration and integrity of the brain connections in OSA patients may be disrupted. The topological alterations of small-world properties may be the mechanism of cognitive impairment in OSA patients. In addition, σ, γ, and λ could be used as a quantitative physiological index for auxiliary clinical diagnoses. Keywords: obstructive sleep apnea, cognitive impairment, small-world, functional MRI, topological propertiesChen LFan XLi HNie SGong HZhang WZeng XLong PPeng DDove Medical Pressarticleobstructive sleep apneacognitive impairmentsmall-worldfunctional MRItopological propertiesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 1471-1482 (2017) |
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DOAJ |
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obstructive sleep apnea cognitive impairment small-world functional MRI topological properties Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
obstructive sleep apnea cognitive impairment small-world functional MRI topological properties Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen L Fan X Li H Nie S Gong H Zhang W Zeng X Long P Peng D Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| description |
Li-Ting Chen,1,* Xiao-Le Fan,2,* Hai-Jun Li,1 Si Nie,1 Hong-Han Gong,1 Wei Zhang,3 Xian-Jun Zeng,1 Ping Long,4 De-Chang Peng1 1Department of Radiology, 2Department of General Surgery, 3Department of Pneumology, 4Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China *These authors contributed equally to this work Purpose: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder that can damage cognitive function. However, the functional network organization remains poorly understood. The aim of this study was to investigate the topological properties of OSA patients using a graph theoretical analysis.Patients and methods: A total of 30 male patients with untreated severe OSA and 25 male education- and age-matched good sleepers (GSs) underwent functional magnetic resonance imaging (MRI) examinations. Clinical and cognitive evaluations were conducted by an experienced psychologist. GRETNA (a toolbox for topological analysis of imaging connectomics) was used to construct the brain functional network and calculate the small-world properties (γ, λ, σ, Eglob, and Eloc). Relationships between these small-world properties and clinical and neuropsychological assessments were investigated in OSA patients.Results: The networks of both OSA patients and GSs exhibited efficient small-world topology over the sparsity range of 0.05–0.40. Compared with GSs, the OSA group had significantly decreased γ, but significantly increased λ and σ. The OSA group’s brain network showed significantly decreased Eglob (P<0.05) over the sparsity range of 0.09–0.15, but significantly increased Eloc over the sparsity range of 0.23–0.40. In OSA patients, γ was significantly negatively correlated with apnea–hypopnea index (AHI; r=−0.326, P=0.015) and Epworth Sleepiness Scale (ESS; r=−0.274, P=0.043), λ was significantly positively correlated with AHI (r=0.373, P=0.005) and ESS (r=0.269, P=0.047), and σ was significantly negatively correlated with AHI (r=−0.363, P=0.007) and ESS (r=−0.295, P=0.029).Conclusion: Our results suggest that the high degree of local integration and integrity of the brain connections in OSA patients may be disrupted. The topological alterations of small-world properties may be the mechanism of cognitive impairment in OSA patients. In addition, σ, γ, and λ could be used as a quantitative physiological index for auxiliary clinical diagnoses. Keywords: obstructive sleep apnea, cognitive impairment, small-world, functional MRI, topological properties |
| format |
article |
| author |
Chen L Fan X Li H Nie S Gong H Zhang W Zeng X Long P Peng D |
| author_facet |
Chen L Fan X Li H Nie S Gong H Zhang W Zeng X Long P Peng D |
| author_sort |
Chen L |
| title |
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| title_short |
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| title_full |
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| title_fullStr |
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| title_full_unstemmed |
Disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fMRI |
| title_sort |
disrupted small-world brain functional network topology in male patients with severe obstructive sleep apnea revealed by resting-state fmri |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/92ad8384182c437f866884c4e72acf6a |
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