Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats

Abstract Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been ra...

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Autores principales:	Kylie R. Baldwin, Allison L. Phillips, Brian Horman, Sheryl E. Arambula, Meghan E. Rebuli, Heather M. Stapleton, Heather B. Patisaul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92af4db10d1c49ac8d07fc47551be162
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spelling	oai:doaj.org-article:92af4db10d1c49ac8d07fc47551be1622021-12-02T12:32:26ZSex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats10.1038/s41598-017-07216-62045-2322https://doaj.org/article/92af4db10d1c49ac8d07fc47551be1622017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07216-6https://doaj.org/toc/2045-2322Abstract Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been raised regarding possible toxicity. We previously reported evidence of sex specific behavioral effects in rats resulting from developmental exposure. The present study expands upon this prior finding by testing for a greater range of behavioral effects, and measuring the accumulation of FM 550 compounds in placental tissue. Wistar rat dams were orally exposed to FM 550 during gestation (0, 300 or 1000 µg/day; GD 9 – 18) for placental measurements or perinatally (0, 100, 300 or 1000 µg/day; GD 9 – PND 21) to assess activity and anxiety-like behaviors. Placental accumulation was dose dependent, and in some cases sex specific, with the brominated components reaching the highest levels. Behavioral changes were predominantly associated with a loss or reversal of sex differences in activity and anxiety-like behaviors. These findings demonstrate that environmental chemicals may sex-dependently accumulate in the placenta. That sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits is a possibility that merits further investigation.Kylie R. BaldwinAllison L. PhillipsBrian HormanSheryl E. ArambulaMeghan E. RebuliHeather M. StapletonHeather B. PatisaulNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kylie R. Baldwin Allison L. Phillips Brian Horman Sheryl E. Arambula Meghan E. Rebuli Heather M. Stapleton Heather B. Patisaul Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
description	Abstract Firemaster® 550 (FM 550) is a commercial flame retardant mixture of brominated and organophosphate compounds applied to polyurethane foam used in furniture and baby products. Due to widespread human exposure, and structural similarities with known endocrine disruptors, concerns have been raised regarding possible toxicity. We previously reported evidence of sex specific behavioral effects in rats resulting from developmental exposure. The present study expands upon this prior finding by testing for a greater range of behavioral effects, and measuring the accumulation of FM 550 compounds in placental tissue. Wistar rat dams were orally exposed to FM 550 during gestation (0, 300 or 1000 µg/day; GD 9 – 18) for placental measurements or perinatally (0, 100, 300 or 1000 µg/day; GD 9 – PND 21) to assess activity and anxiety-like behaviors. Placental accumulation was dose dependent, and in some cases sex specific, with the brominated components reaching the highest levels. Behavioral changes were predominantly associated with a loss or reversal of sex differences in activity and anxiety-like behaviors. These findings demonstrate that environmental chemicals may sex-dependently accumulate in the placenta. That sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits is a possibility that merits further investigation.
format	article
author	Kylie R. Baldwin Allison L. Phillips Brian Horman Sheryl E. Arambula Meghan E. Rebuli Heather M. Stapleton Heather B. Patisaul
author_facet	Kylie R. Baldwin Allison L. Phillips Brian Horman Sheryl E. Arambula Meghan E. Rebuli Heather M. Stapleton Heather B. Patisaul
author_sort	Kylie R. Baldwin
title	Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
title_short	Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
title_full	Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
title_fullStr	Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
title_full_unstemmed	Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
title_sort	sex specific placental accumulation and behavioral effects of developmental firemaster 550 exposure in wistar rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92af4db10d1c49ac8d07fc47551be162
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Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats

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