Antimicrobial properties of Cnestis ferruginea Vahl ex DC

Scientific research into developing new antimicrobials from plants continues to be an interesting area for many scientists. This is because the resistance of microorganisms to anti-infective agents has affected a wide range of conditions, some of which are life-threatening. This study aimed to inves...

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Autores principales:	Akosua Dufie Ankomah, Yaw Duah Boakye, Theresa Appiah Agana, Francis Adu, Christian Agyare
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cnestis ferruginea Biofilm Resistance modifying activity Time-kill kinetics Antimicrobial Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/92afa8074f9746b898697365cc703a07
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spelling	oai:doaj.org-article:92afa8074f9746b898697365cc703a072021-12-02T05:02:20ZAntimicrobial properties of Cnestis ferruginea Vahl ex DC2405-844010.1016/j.heliyon.2021.e08266https://doaj.org/article/92afa8074f9746b898697365cc703a072021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021023690https://doaj.org/toc/2405-8440Scientific research into developing new antimicrobials from plants continues to be an interesting area for many scientists. This is because the resistance of microorganisms to anti-infective agents has affected a wide range of conditions, some of which are life-threatening. This study aimed to investigate the antimicrobial properties of Cnestis ferruginea (CF). Powdered roots of Cnestis ferruginea were extracted with petroleum ether (CFP), ethyl acetate (CFE) and methanol (CFM). The antimicrobial and microbial resistance modifying activity profiles of the extracts were studied against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 4853, Staphylococcus aureus ATCC 25923, clinical strains of Methicillin-Resistant Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumonia, Staphylococcus epidermidis, Proteus mirabilis and Candida albicans. CFP and CFE showed no activity against the test organisms. CFM had mean zones of growth inhibition in the range of 11.0 ± 0.5 to 22.17 ± 0.24 mm against the test organisms. The MIC of CFM was within the range of 0.31 and 5.0 mg/mL, with MBC/MFC range of 2.5–20.0 mg/mL. The time-kill kinetics studies showed CFM is a static agent. At sub-inhibitory concentrations, CFM was able to increase the susceptibility of the test organisms to standard antibiotics from the range of 1–8 folds. CFM reduced the formation of biofilms from 100% to 56.59%, 62.33%, 65.89% and 71.88% against K. pneumonia, S. aureus, E. coli and P. aeruginosa, respectively. The findings of this study show that C. ferruginea possesses antimicrobial activity and therefore gives credence to its folkloric use.Akosua Dufie AnkomahYaw Duah BoakyeTheresa Appiah AganaFrancis AduChristian AgyareElsevierarticleCnestis ferrugineaBiofilmResistance modifying activityTime-kill kineticsAntimicrobialScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08266- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cnestis ferruginea Biofilm Resistance modifying activity Time-kill kinetics Antimicrobial Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Cnestis ferruginea Biofilm Resistance modifying activity Time-kill kinetics Antimicrobial Science (General) Q1-390 Social sciences (General) H1-99 Akosua Dufie Ankomah Yaw Duah Boakye Theresa Appiah Agana Francis Adu Christian Agyare Antimicrobial properties of Cnestis ferruginea Vahl ex DC
description	Scientific research into developing new antimicrobials from plants continues to be an interesting area for many scientists. This is because the resistance of microorganisms to anti-infective agents has affected a wide range of conditions, some of which are life-threatening. This study aimed to investigate the antimicrobial properties of Cnestis ferruginea (CF). Powdered roots of Cnestis ferruginea were extracted with petroleum ether (CFP), ethyl acetate (CFE) and methanol (CFM). The antimicrobial and microbial resistance modifying activity profiles of the extracts were studied against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 4853, Staphylococcus aureus ATCC 25923, clinical strains of Methicillin-Resistant Staphylococcus aureus, Streptococcus pyogenes, Klebsiella pneumonia, Staphylococcus epidermidis, Proteus mirabilis and Candida albicans. CFP and CFE showed no activity against the test organisms. CFM had mean zones of growth inhibition in the range of 11.0 ± 0.5 to 22.17 ± 0.24 mm against the test organisms. The MIC of CFM was within the range of 0.31 and 5.0 mg/mL, with MBC/MFC range of 2.5–20.0 mg/mL. The time-kill kinetics studies showed CFM is a static agent. At sub-inhibitory concentrations, CFM was able to increase the susceptibility of the test organisms to standard antibiotics from the range of 1–8 folds. CFM reduced the formation of biofilms from 100% to 56.59%, 62.33%, 65.89% and 71.88% against K. pneumonia, S. aureus, E. coli and P. aeruginosa, respectively. The findings of this study show that C. ferruginea possesses antimicrobial activity and therefore gives credence to its folkloric use.
format	article
author	Akosua Dufie Ankomah Yaw Duah Boakye Theresa Appiah Agana Francis Adu Christian Agyare
author_facet	Akosua Dufie Ankomah Yaw Duah Boakye Theresa Appiah Agana Francis Adu Christian Agyare
author_sort	Akosua Dufie Ankomah
title	Antimicrobial properties of Cnestis ferruginea Vahl ex DC
title_short	Antimicrobial properties of Cnestis ferruginea Vahl ex DC
title_full	Antimicrobial properties of Cnestis ferruginea Vahl ex DC
title_fullStr	Antimicrobial properties of Cnestis ferruginea Vahl ex DC
title_full_unstemmed	Antimicrobial properties of Cnestis ferruginea Vahl ex DC
title_sort	antimicrobial properties of cnestis ferruginea vahl ex dc
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/92afa8074f9746b898697365cc703a07
work_keys_str_mv	AT akosuadufieankomah antimicrobialpropertiesofcnestisferrugineavahlexdc AT yawduahboakye antimicrobialpropertiesofcnestisferrugineavahlexdc AT theresaappiahagana antimicrobialpropertiesofcnestisferrugineavahlexdc AT francisadu antimicrobialpropertiesofcnestisferrugineavahlexdc AT christianagyare antimicrobialpropertiesofcnestisferrugineavahlexdc
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Antimicrobial properties of Cnestis ferruginea Vahl ex DC

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