Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography

Background: Vascular abnormalities and microvasculopathy are one of the widely accepted factors of diabetic retinopathy (DR). Retinal Neuronal dysfunction and neurodegeneration are also important components in the pathogenesis of DR. However recent investigations show neurodegenerative alterations b...

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Autores principales:	Kalaimamani Ezhilvendhan, Arjun Shenoy, R Rajeshkannan, SaravanaBhava Balachandrachari, Anitha Sathiyamoorthy
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	diabetes mellitus diabetic retinopathy ganglion cell layer-inner plexiform layer thickness macular thickness retinal nerve fiber layer thickness Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/92afbfa7a7ea450fbc62f86705cbcd37
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spelling	oai:doaj.org-article:92afbfa7a7ea450fbc62f86705cbcd372021-11-19T12:15:52ZEvaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography0975-740610.4103/jpbs.jpbs_165_21https://doaj.org/article/92afbfa7a7ea450fbc62f86705cbcd372021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1055;epage=1061;aulast=Ezhilvendhanhttps://doaj.org/toc/0975-7406Background: Vascular abnormalities and microvasculopathy are one of the widely accepted factors of diabetic retinopathy (DR). Retinal Neuronal dysfunction and neurodegeneration are also important components in the pathogenesis of DR. However recent investigations show neurodegenerative alterations before the appearance of microvascular changes in patients having DR. Aims and Objectives: (1) To measure the macular thickness, retinal nerve fiber layer thickness, and ganglion cell complex thickness among patients with type 2 diabetes mellitus using optical coherence tomography. (2) To compare the macular thickness, retinal nerve fiber layer thickness and ganglion cell complex thickness in type 2 diabetic patients with and without DR with normal controls using optical coherence tomography. Materials and Methods: Thirty Patients with type 2 diabetes mellitus without DR, 30 having mild and moderate DR and 30 healthy normals are taken considering the inclusion and exclusion criteria. Macular thickness, retinal nerve fiber layer (RNFL) thickness, ganglion cell layer-inner plexiform layer (GCL-IPL) thickness was measured in each individual and it was compared using one way ANOVA test, post hoc test and Pearson correlation was performed to evaluate the linear correlation between variables and calculated P < 0.05 was regarded as its significance. Results: The average RNFL thickness was 90.27 ± 5.57 and 107.7 ± 5.32 um in diabetic patients and controls respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average RNFL thickness was 89.92 ± 6.62 um in the no DR group and 78.6 ± 3.93 in the DR group (P = 0.339). The average GCL-IPL thickness was 82.65 ± 2.25 um and 92.10 ± 2.41 um in diabetic patients and controls, respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average GCL-IPL thickness was 82.22 ± 2.11 um in the no DR group and 71.55 ± 2.34 in the DR group (P = 0.535). The average macular thickness was 238.03 ± 4.42 and 277.9 ± 5.85 um in diabetic patients and controls, respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average macular thickness was 236.56 ± 4.10 um in the no DR group and 242.8 ± 4.95 um in the DR group (P = 0.585). Conclusion: There was a statistically significant reduction of mean RNFL, GCL-IPL and macular thickness in type 2 diabetic patients with no DR compared with a homogenous control group indicating neuroretinal changes occur before vascular changes of DR.Kalaimamani EzhilvendhanArjun ShenoyR RajeshkannanSaravanaBhava BalachandrachariAnitha SathiyamoorthyWolters Kluwer Medknow Publicationsarticlediabetes mellitusdiabetic retinopathyganglion cell layer-inner plexiform layer thicknessmacular thicknessretinal nerve fiber layer thicknessPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1055-1061 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus diabetic retinopathy ganglion cell layer-inner plexiform layer thickness macular thickness retinal nerve fiber layer thickness Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	diabetes mellitus diabetic retinopathy ganglion cell layer-inner plexiform layer thickness macular thickness retinal nerve fiber layer thickness Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Kalaimamani Ezhilvendhan Arjun Shenoy R Rajeshkannan SaravanaBhava Balachandrachari Anitha Sathiyamoorthy Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
description	Background: Vascular abnormalities and microvasculopathy are one of the widely accepted factors of diabetic retinopathy (DR). Retinal Neuronal dysfunction and neurodegeneration are also important components in the pathogenesis of DR. However recent investigations show neurodegenerative alterations before the appearance of microvascular changes in patients having DR. Aims and Objectives: (1) To measure the macular thickness, retinal nerve fiber layer thickness, and ganglion cell complex thickness among patients with type 2 diabetes mellitus using optical coherence tomography. (2) To compare the macular thickness, retinal nerve fiber layer thickness and ganglion cell complex thickness in type 2 diabetic patients with and without DR with normal controls using optical coherence tomography. Materials and Methods: Thirty Patients with type 2 diabetes mellitus without DR, 30 having mild and moderate DR and 30 healthy normals are taken considering the inclusion and exclusion criteria. Macular thickness, retinal nerve fiber layer (RNFL) thickness, ganglion cell layer-inner plexiform layer (GCL-IPL) thickness was measured in each individual and it was compared using one way ANOVA test, post hoc test and Pearson correlation was performed to evaluate the linear correlation between variables and calculated P < 0.05 was regarded as its significance. Results: The average RNFL thickness was 90.27 ± 5.57 and 107.7 ± 5.32 um in diabetic patients and controls respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average RNFL thickness was 89.92 ± 6.62 um in the no DR group and 78.6 ± 3.93 in the DR group (P = 0.339). The average GCL-IPL thickness was 82.65 ± 2.25 um and 92.10 ± 2.41 um in diabetic patients and controls, respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average GCL-IPL thickness was 82.22 ± 2.11 um in the no DR group and 71.55 ± 2.34 in the DR group (P = 0.535). The average macular thickness was 238.03 ± 4.42 and 277.9 ± 5.85 um in diabetic patients and controls, respectively (P < 0.001). Furthermore, for two different groups of diabetic patients, the average macular thickness was 236.56 ± 4.10 um in the no DR group and 242.8 ± 4.95 um in the DR group (P = 0.585). Conclusion: There was a statistically significant reduction of mean RNFL, GCL-IPL and macular thickness in type 2 diabetic patients with no DR compared with a homogenous control group indicating neuroretinal changes occur before vascular changes of DR.
format	article
author	Kalaimamani Ezhilvendhan Arjun Shenoy R Rajeshkannan SaravanaBhava Balachandrachari Anitha Sathiyamoorthy
author_facet	Kalaimamani Ezhilvendhan Arjun Shenoy R Rajeshkannan SaravanaBhava Balachandrachari Anitha Sathiyamoorthy
author_sort	Kalaimamani Ezhilvendhan
title	Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
title_short	Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
title_full	Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
title_fullStr	Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
title_full_unstemmed	Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
title_sort	evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/92afbfa7a7ea450fbc62f86705cbcd37
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Evaluation of macular thickness, retinal nerve fiber layer and ganglion cell layer thickness in patients among type 2 diabetes mellitus using optical coherence tomography

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