FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus

Endosomes maintain cellular homeostasis by sorting, recycling and degrading endocytosed cargoes. Here the authors show that the SNX27-retromer-WASH complex acts as a hub to direct cargoes to the plasma membrane by blocking their transport to lysosomes and Golgi apparatus.

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Detalles Bibliográficos
Autores principales:	Seongju Lee, Jaerak Chang, Craig Blackstone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92b21014b193476cac6a065734c84f81
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spelling	oai:doaj.org-article:92b21014b193476cac6a065734c84f812021-12-02T15:34:11ZFAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus10.1038/ncomms109392041-1723https://doaj.org/article/92b21014b193476cac6a065734c84f812016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10939https://doaj.org/toc/2041-1723Endosomes maintain cellular homeostasis by sorting, recycling and degrading endocytosed cargoes. Here the authors show that the SNX27-retromer-WASH complex acts as a hub to direct cargoes to the plasma membrane by blocking their transport to lysosomes and Golgi apparatus.Seongju LeeJaerak ChangCraig BlackstoneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seongju Lee Jaerak Chang Craig Blackstone FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
description	Endosomes maintain cellular homeostasis by sorting, recycling and degrading endocytosed cargoes. Here the authors show that the SNX27-retromer-WASH complex acts as a hub to direct cargoes to the plasma membrane by blocking their transport to lysosomes and Golgi apparatus.
format	article
author	Seongju Lee Jaerak Chang Craig Blackstone
author_facet	Seongju Lee Jaerak Chang Craig Blackstone
author_sort	Seongju Lee
title	FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
title_short	FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
title_full	FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
title_fullStr	FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
title_full_unstemmed	FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus
title_sort	fam21 directs snx27–retromer cargoes to the plasma membrane by preventing transport to the golgi apparatus
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/92b21014b193476cac6a065734c84f81
work_keys_str_mv	AT seongjulee fam21directssnx27retromercargoestotheplasmamembranebypreventingtransporttothegolgiapparatus AT jaerakchang fam21directssnx27retromercargoestotheplasmamembranebypreventingtransporttothegolgiapparatus AT craigblackstone fam21directssnx27retromercargoestotheplasmamembranebypreventingtransporttothegolgiapparatus
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FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus

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