Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran

Abstract Background Falcaria vulgaris Bernh among the most important member of Apiaceae family has been used for medical investigation in Iran and some regions in the world. This plant possesses a range of coumarin and flavonoids compounds that have many therapeutic properties such as gastrointestin...

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Autores principales:	Kamran Hosseini, Sanaz Jasori, Abbas Delazar, Parina Asgharian, Vahideh Tarhriz
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Falcaria vulgaris Bernh Cancerous cells GC-MS Cytotoxicity Apoptosis Volatile compounds Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/92bb39fad5d24b43b0c6166dc56ce054
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spelling	oai:doaj.org-article:92bb39fad5d24b43b0c6166dc56ce0542021-12-05T12:23:59ZPhytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran10.1186/s12906-021-03464-22662-7671https://doaj.org/article/92bb39fad5d24b43b0c6166dc56ce0542021-12-01T00:00:00Zhttps://doi.org/10.1186/s12906-021-03464-2https://doaj.org/toc/2662-7671Abstract Background Falcaria vulgaris Bernh among the most important member of Apiaceae family has been used for medical investigation in Iran and some regions in the world. This plant possesses a range of coumarin and flavonoids compounds that have many therapeutic properties such as gastrointestinal and liver diseases, skin ulcers, gastric ulcers, and intestinal inflammation. It has also been found that these compounds lead to cytotoxic effects. Objective This study contains concentrates on the cytotoxic effect and induction of apoptosis on cancerous cells (SW-872) through various extracts and essential oil of Falcaria vulgaris Bernh. It considers the volatile compounds of effective samples. Methods The shoot of the plant was extracted by the Soxhlet apparatus and its essential oil was taken by the Clevenger apparatus. The cytotoxicity of the samples was evaluated by the MTT method and the mechanism of cancer cell death by flow cytometry and finally, the volatile compounds of essential oils and effective extracts were identified by GC-MS. Results The results demonstrated that n-Hexane extract and 40% VLC fraction had the greatest cytotoxic effect on SW-872 cells. While, the most abundant volatile compounds in essential oil and 40% VLC fraction of n-Hexane extract were terpenoid compounds like (+) spathulenol and caryophyllene oxide, in n-Hexane extract tetradecan, and spathulenol were the most, respectively. Conclusion The fraction of 40% n-Hexane was in a concentration-dependent manner and significantly with controlling cells inhibited the growth of cancer cells. A plausible explanation could be made to account for this effect. This inhibition was made through induction of apoptosis and due to the presence of effective volatile compounds such as terpenoids and non-terpenoids which could be considered as valuable natural sources for the isolation of anti-cancer compounds.Kamran HosseiniSanaz JasoriAbbas DelazarParina AsgharianVahideh TarhrizBMCarticleFalcaria vulgaris BernhCancerous cellsGC-MSCytotoxicityApoptosisVolatile compoundsOther systems of medicineRZ201-999ENBMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Falcaria vulgaris Bernh Cancerous cells GC-MS Cytotoxicity Apoptosis Volatile compounds Other systems of medicine RZ201-999
spellingShingle	Falcaria vulgaris Bernh Cancerous cells GC-MS Cytotoxicity Apoptosis Volatile compounds Other systems of medicine RZ201-999 Kamran Hosseini Sanaz Jasori Abbas Delazar Parina Asgharian Vahideh Tarhriz Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
description	Abstract Background Falcaria vulgaris Bernh among the most important member of Apiaceae family has been used for medical investigation in Iran and some regions in the world. This plant possesses a range of coumarin and flavonoids compounds that have many therapeutic properties such as gastrointestinal and liver diseases, skin ulcers, gastric ulcers, and intestinal inflammation. It has also been found that these compounds lead to cytotoxic effects. Objective This study contains concentrates on the cytotoxic effect and induction of apoptosis on cancerous cells (SW-872) through various extracts and essential oil of Falcaria vulgaris Bernh. It considers the volatile compounds of effective samples. Methods The shoot of the plant was extracted by the Soxhlet apparatus and its essential oil was taken by the Clevenger apparatus. The cytotoxicity of the samples was evaluated by the MTT method and the mechanism of cancer cell death by flow cytometry and finally, the volatile compounds of essential oils and effective extracts were identified by GC-MS. Results The results demonstrated that n-Hexane extract and 40% VLC fraction had the greatest cytotoxic effect on SW-872 cells. While, the most abundant volatile compounds in essential oil and 40% VLC fraction of n-Hexane extract were terpenoid compounds like (+) spathulenol and caryophyllene oxide, in n-Hexane extract tetradecan, and spathulenol were the most, respectively. Conclusion The fraction of 40% n-Hexane was in a concentration-dependent manner and significantly with controlling cells inhibited the growth of cancer cells. A plausible explanation could be made to account for this effect. This inhibition was made through induction of apoptosis and due to the presence of effective volatile compounds such as terpenoids and non-terpenoids which could be considered as valuable natural sources for the isolation of anti-cancer compounds.
format	article
author	Kamran Hosseini Sanaz Jasori Abbas Delazar Parina Asgharian Vahideh Tarhriz
author_facet	Kamran Hosseini Sanaz Jasori Abbas Delazar Parina Asgharian Vahideh Tarhriz
author_sort	Kamran Hosseini
title	Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
title_short	Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
title_full	Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
title_fullStr	Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
title_full_unstemmed	Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran
title_sort	phytochemical analysis and anticancer activity of falcaria vulgaris bernh growing in moghan plain, northwest of iran
publisher	BMC
publishDate	2021
url	https://doaj.org/article/92bb39fad5d24b43b0c6166dc56ce054
work_keys_str_mv	AT kamranhosseini phytochemicalanalysisandanticanceractivityoffalcariavulgarisbernhgrowinginmoghanplainnorthwestofiran AT sanazjasori phytochemicalanalysisandanticanceractivityoffalcariavulgarisbernhgrowinginmoghanplainnorthwestofiran AT abbasdelazar phytochemicalanalysisandanticanceractivityoffalcariavulgarisbernhgrowinginmoghanplainnorthwestofiran AT parinaasgharian phytochemicalanalysisandanticanceractivityoffalcariavulgarisbernhgrowinginmoghanplainnorthwestofiran AT vahidehtarhriz phytochemicalanalysisandanticanceractivityoffalcariavulgarisbernhgrowinginmoghanplainnorthwestofiran
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Phytochemical analysis and anticancer activity of Falcaria vulgaris Bernh growing in Moghan plain, northwest of Iran

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