Heterochromatin is a quantitative trait associated with spontaneous epiallele formation

The molecular origins of epialleles remain unknown. Here, the authors show that a positive feedback loop between H3K9me2 and CMT2/3 is a major contributing factor to the origins of spontaneous epialleles and that heterochromatin is a quantitative trait associated with spontaneous epiallele formation...

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Main Authors: Yinwen Zhang, Hosung Jang, Rui Xiao, Ioanna Kakoulidou, Robert S. Piecyk, Frank Johannes, Robert J. Schmitz
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/92bbdcf244a549d7bd6b64dcded0745b
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spelling oai:doaj.org-article:92bbdcf244a549d7bd6b64dcded0745b2021-12-05T12:22:32ZHeterochromatin is a quantitative trait associated with spontaneous epiallele formation10.1038/s41467-021-27320-62041-1723https://doaj.org/article/92bbdcf244a549d7bd6b64dcded0745b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27320-6https://doaj.org/toc/2041-1723The molecular origins of epialleles remain unknown. Here, the authors show that a positive feedback loop between H3K9me2 and CMT2/3 is a major contributing factor to the origins of spontaneous epialleles and that heterochromatin is a quantitative trait associated with spontaneous epiallele formation.Yinwen ZhangHosung JangRui XiaoIoanna KakoulidouRobert S. PiecykFrank JohannesRobert J. SchmitzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yinwen Zhang
Hosung Jang
Rui Xiao
Ioanna Kakoulidou
Robert S. Piecyk
Frank Johannes
Robert J. Schmitz
Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
description The molecular origins of epialleles remain unknown. Here, the authors show that a positive feedback loop between H3K9me2 and CMT2/3 is a major contributing factor to the origins of spontaneous epialleles and that heterochromatin is a quantitative trait associated with spontaneous epiallele formation.
format article
author Yinwen Zhang
Hosung Jang
Rui Xiao
Ioanna Kakoulidou
Robert S. Piecyk
Frank Johannes
Robert J. Schmitz
author_facet Yinwen Zhang
Hosung Jang
Rui Xiao
Ioanna Kakoulidou
Robert S. Piecyk
Frank Johannes
Robert J. Schmitz
author_sort Yinwen Zhang
title Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
title_short Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
title_full Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
title_fullStr Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
title_full_unstemmed Heterochromatin is a quantitative trait associated with spontaneous epiallele formation
title_sort heterochromatin is a quantitative trait associated with spontaneous epiallele formation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/92bbdcf244a549d7bd6b64dcded0745b
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AT ioannakakoulidou heterochromatinisaquantitativetraitassociatedwithspontaneousepialleleformation
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