Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens

Abstract The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity. A total of 255 one-day-old male Cobb 500 broiler chickens were fed on fish oil (FO)-, flaxseed oil-en...

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Autores principales:	Hanan Al-Khalaifah, Afaf Al-Nasser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92bc05daf8474fdebd95f42123cc69ea
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spelling	oai:doaj.org-article:92bc05daf8474fdebd95f42123cc69ea2021-12-02T14:58:45ZDietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens10.1038/s41598-021-89381-32045-2322https://doaj.org/article/92bc05daf8474fdebd95f42123cc69ea2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89381-3https://doaj.org/toc/2045-2322Abstract The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity. A total of 255 one-day-old male Cobb 500 broiler chickens were fed on fish oil (FO)-, flaxseed oil-enriched diets at 50 and 19 g/kg, respectively, in addition to the soybean-based control diet. At slaughter, samples of blood and spleen were harvested from 20 birds/treatment (n = 20). The immune tissues' fatty acid profile was analyzed by gas chromatography, and the cytotoxic cell activity was investigated. The results showed that supplementing broiler chickens with diets rich in n-3 PUFA had a substantial effect on the broiler immune tissues' fatty acid profile. Cytotoxic cell activity was significantly higher in splenocytes and peripheral blood mononuclear cells (PBMCs) from broilers fed flaxseed oil than those provided FO and the soybean control diet. These results suggest that flaxseed oil may be used to enrich chickens with n-3 PUFA and improve the immune status of chicken flocks to resist diseases.Hanan Al-KhalaifahAfaf Al-NasserNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hanan Al-Khalaifah Afaf Al-Nasser Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
description	Abstract The current study aims to investigate the effects of dietary source of n-3 polyunsaturated fatty acids (PUFA) on immune response in broiler chickens, represented by cytotoxic cell activity. A total of 255 one-day-old male Cobb 500 broiler chickens were fed on fish oil (FO)-, flaxseed oil-enriched diets at 50 and 19 g/kg, respectively, in addition to the soybean-based control diet. At slaughter, samples of blood and spleen were harvested from 20 birds/treatment (n = 20). The immune tissues' fatty acid profile was analyzed by gas chromatography, and the cytotoxic cell activity was investigated. The results showed that supplementing broiler chickens with diets rich in n-3 PUFA had a substantial effect on the broiler immune tissues' fatty acid profile. Cytotoxic cell activity was significantly higher in splenocytes and peripheral blood mononuclear cells (PBMCs) from broilers fed flaxseed oil than those provided FO and the soybean control diet. These results suggest that flaxseed oil may be used to enrich chickens with n-3 PUFA and improve the immune status of chicken flocks to resist diseases.
format	article
author	Hanan Al-Khalaifah Afaf Al-Nasser
author_facet	Hanan Al-Khalaifah Afaf Al-Nasser
author_sort	Hanan Al-Khalaifah
title	Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
title_short	Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
title_full	Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
title_fullStr	Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
title_full_unstemmed	Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
title_sort	dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92bc05daf8474fdebd95f42123cc69ea
work_keys_str_mv	AT hananalkhalaifah dietarysourceofpolyunsaturatedfattyacidsinfluencescellcytotoxicityinbroilerchickens AT afafalnasser dietarysourceofpolyunsaturatedfattyacidsinfluencescellcytotoxicityinbroilerchickens
_version_	1718389280037928960

Dietary source of polyunsaturated fatty acids influences cell cytotoxicity in broiler chickens

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