Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis

Joint replacement surgery is one of the orthopedic surgeries with high successful rates; however, wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant. The implant-derived particulate debris such as ultrahigh molecular weight polyethylene...

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Autores principales:	Kuo-Yang Sun, Yizhang Wu, Jia Xu, Wenfang Xiong, Wei Xu, Jiawei Li, Ziying Sun, Zhongyang Lv, X.S. Wu, Qing Jiang, Hong-Ling Cai, Dongquan Shi
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Periprosthetic osteolysis MXene Niobium carbide Osteoclastogenesis Reactive oxygen species (ROS) Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/92bc45c501764a99b74a461149b32854
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id	oai:doaj.org-article:92bc45c501764a99b74a461149b32854
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spelling	oai:doaj.org-article:92bc45c501764a99b74a461149b328542021-11-04T04:35:27ZNiobium carbide (MXene) reduces UHMWPE particle-induced osteolysis2452-199X10.1016/j.bioactmat.2021.06.016https://doaj.org/article/92bc45c501764a99b74a461149b328542022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003029https://doaj.org/toc/2452-199XJoint replacement surgery is one of the orthopedic surgeries with high successful rates; however, wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant. The implant-derived particulate debris such as ultrahigh molecular weight polyethylene (UHMWPE) can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species (ROS). ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of osteolysis. In this work, we develop the few-layered Nb2C (FNC) as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS adsorption. Moreover, local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial model. In sum, our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.Kuo-Yang SunYizhang WuJia XuWenfang XiongWei XuJiawei LiZiying SunZhongyang LvX.S. WuQing JiangHong-Ling CaiDongquan ShiKeAi Communications Co., Ltd.articlePeriprosthetic osteolysisMXeneNiobium carbideOsteoclastogenesisReactive oxygen species (ROS)Materials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 435-448 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Periprosthetic osteolysis MXene Niobium carbide Osteoclastogenesis Reactive oxygen species (ROS) Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Periprosthetic osteolysis MXene Niobium carbide Osteoclastogenesis Reactive oxygen species (ROS) Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Kuo-Yang Sun Yizhang Wu Jia Xu Wenfang Xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv X.S. Wu Qing Jiang Hong-Ling Cai Dongquan Shi Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
description	Joint replacement surgery is one of the orthopedic surgeries with high successful rates; however, wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the implant. The implant-derived particulate debris such as ultrahigh molecular weight polyethylene (UHMWPE) can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species (ROS). ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of osteolysis. In this work, we develop the few-layered Nb2C (FNC) as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS adsorption. Moreover, local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial model. In sum, our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.
format	article
author	Kuo-Yang Sun Yizhang Wu Jia Xu Wenfang Xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv X.S. Wu Qing Jiang Hong-Ling Cai Dongquan Shi
author_facet	Kuo-Yang Sun Yizhang Wu Jia Xu Wenfang Xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv X.S. Wu Qing Jiang Hong-Ling Cai Dongquan Shi
author_sort	Kuo-Yang Sun
title	Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
title_short	Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
title_full	Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
title_fullStr	Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
title_full_unstemmed	Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis
title_sort	niobium carbide (mxene) reduces uhmwpe particle-induced osteolysis
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/92bc45c501764a99b74a461149b32854
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Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis

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