Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci.

Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci.

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Chromatin accessibility and gene expression in relevant cell contexts can guide identification of regulatory elements and mechanisms at genome-wide association study (GWAS) loci. To identify regulatory elements that display differential activity across adipocyte differentiation, we performed ATAC-se...

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Autores principales: Hannah J Perrin, Kevin W Currin, Swarooparani Vadlamudi, Gautam K Pandey, Kenneth K Ng, Martin Wabitsch, Markku Laakso, Michael I Love, Karen L Mohlke
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/92bcda09d29846e985b1f396bf252601
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