Frontal brain dysfunction in alcoholism with and without antisocial personality disorder

Marlene Oscar-Berman1,2, Mary M Valmas1,2, Kayle s Sawyer1,2, Shalene M Kirkley1, David A Gansler3, Diane Merritt1,2, Ashley Couture11Department of Veterans Affairs Healthcare System, Boston Campus, Boston, MA, USA; 2Boston University School of Medicine, Boston, MA, USA; 3Suffolk University, Boston,...

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Autores principales:	Marlene Oscar-Berman, Mary M Valmas, Kayle s Sawyer, Shalene M Kirkley, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/92c090bd119a4e68bb9415241767650b
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spelling	oai:doaj.org-article:92c090bd119a4e68bb9415241767650b2021-12-02T01:04:31ZFrontal brain dysfunction in alcoholism with and without antisocial personality disorder1176-63281178-2021https://doaj.org/article/92c090bd119a4e68bb9415241767650b2009-05-01T00:00:00Zhttp://www.dovepress.com/frontal-brain-dysfunction-in-alcoholism-with-and-without-antisocial-pe-a3161https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Marlene Oscar-Berman1,2, Mary M Valmas1,2, Kayle s Sawyer1,2, Shalene M Kirkley1, David A Gansler3, Diane Merritt1,2, Ashley Couture11Department of Veterans Affairs Healthcare System, Boston Campus, Boston, MA, USA; 2Boston University School of Medicine, Boston, MA, USA; 3Suffolk University, Boston, MA, USAAbstract: Alcoholism and antisocial personality disorder (ASPD) often are comorbid conditions. Alcoholics, as well as nonalcoholic individuals with ASPD, exhibit behaviors associated with prefrontal brain dysfunction such as increased impulsivity and emotional dysregulation. These behaviors can influence drinking motives and patterns of consumption. Because few studies have investigated the combined association between ASPD and alcoholism on neuropsychological functioning, this study examined the influence of ASPD symptoms and alcoholism on tests sensitive to frontal brain deficits. The participants were 345 men and women. Of them, 144 were abstinent alcoholics (66 with ASPD symptoms), and 201 were nonalcoholic control participants (24 with ASPD symptoms). Performances among the groups were examined with Trails A and B tests, the Wisconsin Card Sorting Test, the Controlled Oral Word Association Test, the Ruff Figural Fluency Test, and Performance subtests of the Wechsler Adult Intelligence Scale. Measures of affect also were obtained. Multiple regression analyses showed that alcoholism, specific drinking variables (amount and duration of heavy drinking), and ASPD were significant predictors of frontal system and affective abnormalities. These effects were different for men and women. The findings suggested that the combination of alcoholism and ASPD leads to greater deficits than the sum of each. &nbsp;Keywords: alcoholism, antisocial personality disorder (ASPD), frontal brain system, neuropsychological deficits, reward system Marlene Oscar-BermanMary M ValmasKayle s SawyerShalene M Kirkleyet al.Dove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 309-326 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Marlene Oscar-Berman Mary M Valmas Kayle s Sawyer Shalene M Kirkley et al. Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
description	Marlene Oscar-Berman1,2, Mary M Valmas1,2, Kayle s Sawyer1,2, Shalene M Kirkley1, David A Gansler3, Diane Merritt1,2, Ashley Couture11Department of Veterans Affairs Healthcare System, Boston Campus, Boston, MA, USA; 2Boston University School of Medicine, Boston, MA, USA; 3Suffolk University, Boston, MA, USAAbstract: Alcoholism and antisocial personality disorder (ASPD) often are comorbid conditions. Alcoholics, as well as nonalcoholic individuals with ASPD, exhibit behaviors associated with prefrontal brain dysfunction such as increased impulsivity and emotional dysregulation. These behaviors can influence drinking motives and patterns of consumption. Because few studies have investigated the combined association between ASPD and alcoholism on neuropsychological functioning, this study examined the influence of ASPD symptoms and alcoholism on tests sensitive to frontal brain deficits. The participants were 345 men and women. Of them, 144 were abstinent alcoholics (66 with ASPD symptoms), and 201 were nonalcoholic control participants (24 with ASPD symptoms). Performances among the groups were examined with Trails A and B tests, the Wisconsin Card Sorting Test, the Controlled Oral Word Association Test, the Ruff Figural Fluency Test, and Performance subtests of the Wechsler Adult Intelligence Scale. Measures of affect also were obtained. Multiple regression analyses showed that alcoholism, specific drinking variables (amount and duration of heavy drinking), and ASPD were significant predictors of frontal system and affective abnormalities. These effects were different for men and women. The findings suggested that the combination of alcoholism and ASPD leads to greater deficits than the sum of each. &nbsp;Keywords: alcoholism, antisocial personality disorder (ASPD), frontal brain system, neuropsychological deficits, reward system
format	article
author	Marlene Oscar-Berman Mary M Valmas Kayle s Sawyer Shalene M Kirkley et al.
author_facet	Marlene Oscar-Berman Mary M Valmas Kayle s Sawyer Shalene M Kirkley et al.
author_sort	Marlene Oscar-Berman
title	Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
title_short	Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
title_full	Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
title_fullStr	Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
title_full_unstemmed	Frontal brain dysfunction in alcoholism with and without antisocial personality disorder
title_sort	frontal brain dysfunction in alcoholism with and without antisocial personality disorder
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/92c090bd119a4e68bb9415241767650b
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Frontal brain dysfunction in alcoholism with and without antisocial personality disorder

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