Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.

<h4>Background</h4>Huntington's disease (HD) is an inherited, progressive neurodegenerative disease that has no cure. Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Marie N N Hellem, Tua Vinther-Jensen, Lasse Anderberg, Esben Budtz-Jørgensen, Lena E Hjermind, Vibeke Andrée Larsen, Jørgen E Nielsen, Ian Law
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92c324f278e24176875b8adc52bf1c98
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92c324f278e24176875b8adc52bf1c98
record_format	dspace
spelling	oai:doaj.org-article:92c324f278e24176875b8adc52bf1c982021-12-02T20:07:09ZHybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.1932-620310.1371/journal.pone.0252683https://doaj.org/article/92c324f278e24176875b8adc52bf1c982021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252683https://doaj.org/toc/1932-6203<h4>Background</h4>Huntington's disease (HD) is an inherited, progressive neurodegenerative disease that has no cure. Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.<h4>Objective</h4>Evaluation of partial volume effects in a cohort of premanifest HD gene-expansion carriers (HDGECs).<h4>Methods</h4>21 HDGECs and 17 controls had a hybrid 2-[18F]FDG PET/MRI scan performed. Volume measurements and striatal metabolism, both corrected and uncorrected for partial volume effect were correlated to an estimate of disease burden, the CAG age product scaled (CAPS).<h4>Results</h4>We found significantly reduced striatal metabolism in HDGECs, but not in striatal volume. There was a negative correlation between the CAPS and striatal metabolism, both corrected and uncorrected for the partial volume effect. The partial volume effect was largest in the smallest structures and increased the difference in metabolism between the HDGEC with high and low CAPS scores. Statistical parametric mapping confirmed the results.<h4>Conclusions</h4>A hybrid 2-[18F]FDG PET/MRI scan provides simultaneous information on structure and metabolism. Using this approach for the first time on HDGECs, we highlight the importance of partial volume effect correction in order not to underestimate the standardized uptake value and thereby the risk of overestimating the metabolic effect on the striatal structures, which potentially could bias studies determining imaging outcome measures of interventions in HDGECs and probably also symptomatic HD.Marie N N HellemTua Vinther-JensenLasse AnderbergEsben Budtz-JørgensenLena E HjermindVibeke Andrée LarsenJørgen E NielsenIan LawPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252683 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie N N Hellem Tua Vinther-Jensen Lasse Anderberg Esben Budtz-Jørgensen Lena E Hjermind Vibeke Andrée Larsen Jørgen E Nielsen Ian Law Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
description	<h4>Background</h4>Huntington's disease (HD) is an inherited, progressive neurodegenerative disease that has no cure. Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.<h4>Objective</h4>Evaluation of partial volume effects in a cohort of premanifest HD gene-expansion carriers (HDGECs).<h4>Methods</h4>21 HDGECs and 17 controls had a hybrid 2-[18F]FDG PET/MRI scan performed. Volume measurements and striatal metabolism, both corrected and uncorrected for partial volume effect were correlated to an estimate of disease burden, the CAG age product scaled (CAPS).<h4>Results</h4>We found significantly reduced striatal metabolism in HDGECs, but not in striatal volume. There was a negative correlation between the CAPS and striatal metabolism, both corrected and uncorrected for the partial volume effect. The partial volume effect was largest in the smallest structures and increased the difference in metabolism between the HDGEC with high and low CAPS scores. Statistical parametric mapping confirmed the results.<h4>Conclusions</h4>A hybrid 2-[18F]FDG PET/MRI scan provides simultaneous information on structure and metabolism. Using this approach for the first time on HDGECs, we highlight the importance of partial volume effect correction in order not to underestimate the standardized uptake value and thereby the risk of overestimating the metabolic effect on the striatal structures, which potentially could bias studies determining imaging outcome measures of interventions in HDGECs and probably also symptomatic HD.
format	article
author	Marie N N Hellem Tua Vinther-Jensen Lasse Anderberg Esben Budtz-Jørgensen Lena E Hjermind Vibeke Andrée Larsen Jørgen E Nielsen Ian Law
author_facet	Marie N N Hellem Tua Vinther-Jensen Lasse Anderberg Esben Budtz-Jørgensen Lena E Hjermind Vibeke Andrée Larsen Jørgen E Nielsen Ian Law
author_sort	Marie N N Hellem
title	Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
title_short	Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
title_full	Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
title_fullStr	Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
title_full_unstemmed	Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
title_sort	hybrid 2-[18f] fdg pet/mri in premanifest huntington's disease gene-expansion carriers: the significance of partial volume correction.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/92c324f278e24176875b8adc52bf1c98
work_keys_str_mv	AT mariennhellem hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT tuavintherjensen hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT lasseanderberg hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT esbenbudtzjørgensen hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT lenaehjermind hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT vibekeandreelarsen hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT jørgenenielsen hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection AT ianlaw hybrid218ffdgpetmriinpremanifesthuntingtonsdiseasegeneexpansioncarriersthesignificanceofpartialvolumecorrection
_version_	1718375316754268160

Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.

Ejemplares similares