Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatima Rizvi, Elissa Everton, Anna R. Smith, Hua Liu, Elizabeth Osota, Mitchell Beattie, Ying Tam, Norbert Pardi, Drew Weissman, Valerie Gouon-Evans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92c5e809fade4febb8867b9abf7c2367
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92c5e809fade4febb8867b9abf7c2367
record_format	dspace
spelling	oai:doaj.org-article:92c5e809fade4febb8867b9abf7c23672021-12-02T10:48:27ZMurine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA10.1038/s41467-021-20903-32041-1723https://doaj.org/article/92c5e809fade4febb8867b9abf7c23672021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20903-3https://doaj.org/toc/2041-1723When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.Fatima RizviElissa EvertonAnna R. SmithHua LiuElizabeth OsotaMitchell BeattieYing TamNorbert PardiDrew WeissmanValerie Gouon-EvansNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
description	When severely or chronically injured, the liver loses ability to regenerate. Here, the authors utilize transient lipid nanoparticle-enclosed HGF and EGF-encoding mRNA delivery to induce hepatocyte proliferation and harness recovery of liver function in murine acute and chronic liver injury models.
format	article
author	Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans
author_facet	Fatima Rizvi Elissa Everton Anna R. Smith Hua Liu Elizabeth Osota Mitchell Beattie Ying Tam Norbert Pardi Drew Weissman Valerie Gouon-Evans
author_sort	Fatima Rizvi
title	Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
title_short	Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
title_full	Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
title_fullStr	Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
title_full_unstemmed	Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA
title_sort	murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mrna
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92c5e809fade4febb8867b9abf7c2367
work_keys_str_mv	AT fatimarizvi murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT elissaeverton murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT annarsmith murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT hualiu murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT elizabethosota murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT mitchellbeattie murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT yingtam murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT norbertpardi murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT drewweissman murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna AT valeriegouonevans murineliverrepairviatransientactivationofregenerativepathwaysinhepatocytesusinglipidnanoparticlecomplexednucleosidemodifiedmrna
_version_	1718396663171645440

Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA

Ejemplares similares