Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.

<h4>Background</h4>The 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes. The 12Ala allele carriers display a significantly i...

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Autores principales:	Agnieszka Maciejewska-Karlowska, Marek Sawczuk, Pawel Cieszczyk, Aleksandra Zarebska, Stanislaw Sawczyn
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92c6ca6c669541768eeb867c2e0d5b02
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spelling	oai:doaj.org-article:92c6ca6c669541768eeb867c2e0d5b022021-11-18T07:41:36ZAssociation between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.1932-620310.1371/journal.pone.0067172https://doaj.org/article/92c6ca6c669541768eeb867c2e0d5b022013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23799144/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes. The 12Ala allele carriers display a significantly improved insulin sensitivity that may result in better glucose utilisation in working skeletal muscles. We hypothesise that the PPARG 12Ala allele could be associated with strength athlete status in Polish athletes.<h4>Methodology</h4>The genotype distribution of PPARG Pro12Ala was examined in 660 Polish athletes. The athletes were stratified into four subgroups: endurance, strength-endurance, sprint-strength and strength. Control samples were prepared from 684 unrelated sedentary volunteers. A χ(2) test was used to compare the PPARG Pro12Ala allele and genotype frequencies between the different groups of athletes and control subjects. Bonferroni's correction for multiple testing was applied.<h4>Results</h4>A statistically significant higher frequency of PPARG 12Ala alleles was observed in the subgroup of strength athletes performing short-term and very intense exertion characterised by predominant anaerobic energy production (13.2% vs. 7.5% in controls; P = 0.0007).<h4>Conclusion</h4>The PPARG 12Ala allele may be a relevant genetic factor favouring strength abilities in professional athletes, especially in terms of insulin-dependent metabolism, a shift of the energy balance towards glucose utilisation and the development of a favourable weight-to-strength ratio.Agnieszka Maciejewska-KarlowskaMarek SawczukPawel CieszczykAleksandra ZarebskaStanislaw SawczynPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e67172 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agnieszka Maciejewska-Karlowska Marek Sawczuk Pawel Cieszczyk Aleksandra Zarebska Stanislaw Sawczyn Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
description	<h4>Background</h4>The 12Ala allele of the Peroxisome Proliferator-Activated Receptor gamma gene (PPARG) Pro12Ala polymorphism produces a decreased binding affinity of the PPARγ2 protein, resulting in low activation of the target genes. The 12Ala allele carriers display a significantly improved insulin sensitivity that may result in better glucose utilisation in working skeletal muscles. We hypothesise that the PPARG 12Ala allele could be associated with strength athlete status in Polish athletes.<h4>Methodology</h4>The genotype distribution of PPARG Pro12Ala was examined in 660 Polish athletes. The athletes were stratified into four subgroups: endurance, strength-endurance, sprint-strength and strength. Control samples were prepared from 684 unrelated sedentary volunteers. A χ(2) test was used to compare the PPARG Pro12Ala allele and genotype frequencies between the different groups of athletes and control subjects. Bonferroni's correction for multiple testing was applied.<h4>Results</h4>A statistically significant higher frequency of PPARG 12Ala alleles was observed in the subgroup of strength athletes performing short-term and very intense exertion characterised by predominant anaerobic energy production (13.2% vs. 7.5% in controls; P = 0.0007).<h4>Conclusion</h4>The PPARG 12Ala allele may be a relevant genetic factor favouring strength abilities in professional athletes, especially in terms of insulin-dependent metabolism, a shift of the energy balance towards glucose utilisation and the development of a favourable weight-to-strength ratio.
format	article
author	Agnieszka Maciejewska-Karlowska Marek Sawczuk Pawel Cieszczyk Aleksandra Zarebska Stanislaw Sawczyn
author_facet	Agnieszka Maciejewska-Karlowska Marek Sawczuk Pawel Cieszczyk Aleksandra Zarebska Stanislaw Sawczyn
author_sort	Agnieszka Maciejewska-Karlowska
title	Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
title_short	Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
title_full	Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
title_fullStr	Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
title_full_unstemmed	Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
title_sort	association between the pro12ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/92c6ca6c669541768eeb867c2e0d5b02
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Association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene and strength athlete status.

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