Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum

Abstract The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts. Stellate cells showed intrinsic pacemaking, along with characteri...

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Autores principales:	Martina Francesca Rizza, Francesca Locatelli, Stefano Masoli, Diana Sánchez-Ponce, Alberto Muñoz, Francesca Prestori, Egidio D’Angelo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92c916d78a9341639a02a6c815974b12
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spelling	oai:doaj.org-article:92c916d78a9341639a02a6c815974b122021-12-02T10:54:14ZStellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum10.1038/s41598-021-83209-w2045-2322https://doaj.org/article/92c916d78a9341639a02a6c815974b122021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83209-whttps://doaj.org/toc/2045-2322Abstract The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts. Stellate cells showed intrinsic pacemaking, along with characteristic responses to depolarization and hyperpolarization, and showed a marked short-term facilitation during repetitive parallel fiber transmission. Spikes were emitted after a lag and only at high frequency, making stellate cells to operate as delay-high-pass filters. A detailed computational model summarizing these physiological properties allowed to explore different functional configurations of the parallel fiber—stellate cell—Purkinje cell circuit. Simulations showed that, following parallel fiber stimulation, Purkinje cells almost linearly increased their response with input frequency, but such an increase was inhibited by stellate cells, which leveled the Purkinje cell gain curve to its 4 Hz value. When reciprocal inhibitory connections between stellate cells were activated, the control of stellate cells over Purkinje cell discharge was maintained only at very high frequencies. These simulations thus predict a new role for stellate cells, which could endow the molecular layer with low-pass and band-pass filtering properties regulating Purkinje cell gain and, along with this, also burst delay and the burst-pause responses pattern.Martina Francesca RizzaFrancesca LocatelliStefano MasoliDiana Sánchez-PonceAlberto MuñozFrancesca PrestoriEgidio D’AngeloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martina Francesca Rizza Francesca Locatelli Stefano Masoli Diana Sánchez-Ponce Alberto Muñoz Francesca Prestori Egidio D’Angelo Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
description	Abstract The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts. Stellate cells showed intrinsic pacemaking, along with characteristic responses to depolarization and hyperpolarization, and showed a marked short-term facilitation during repetitive parallel fiber transmission. Spikes were emitted after a lag and only at high frequency, making stellate cells to operate as delay-high-pass filters. A detailed computational model summarizing these physiological properties allowed to explore different functional configurations of the parallel fiber—stellate cell—Purkinje cell circuit. Simulations showed that, following parallel fiber stimulation, Purkinje cells almost linearly increased their response with input frequency, but such an increase was inhibited by stellate cells, which leveled the Purkinje cell gain curve to its 4 Hz value. When reciprocal inhibitory connections between stellate cells were activated, the control of stellate cells over Purkinje cell discharge was maintained only at very high frequencies. These simulations thus predict a new role for stellate cells, which could endow the molecular layer with low-pass and band-pass filtering properties regulating Purkinje cell gain and, along with this, also burst delay and the burst-pause responses pattern.
format	article
author	Martina Francesca Rizza Francesca Locatelli Stefano Masoli Diana Sánchez-Ponce Alberto Muñoz Francesca Prestori Egidio D’Angelo
author_facet	Martina Francesca Rizza Francesca Locatelli Stefano Masoli Diana Sánchez-Ponce Alberto Muñoz Francesca Prestori Egidio D’Angelo
author_sort	Martina Francesca Rizza
title	Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
title_short	Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
title_full	Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
title_fullStr	Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
title_full_unstemmed	Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
title_sort	stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92c916d78a9341639a02a6c815974b12
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Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum

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