Ancient Transcription Factors in the News

ABSTRACT In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with numerous cotranscriptional processes that ultimately determine the transcript fate. Housekeeping NusG factors regulate expressi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irina Artsimovitch, Stefan H. Knauer
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	NusG RfaH antitermination transcription translation Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/92c9c2ae0c004a7696786d23e97d6ea8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92c9c2ae0c004a7696786d23e97d6ea8
record_format	dspace
spelling	oai:doaj.org-article:92c9c2ae0c004a7696786d23e97d6ea82021-11-15T15:55:14ZAncient Transcription Factors in the News10.1128/mBio.01547-182150-7511https://doaj.org/article/92c9c2ae0c004a7696786d23e97d6ea82019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01547-18https://doaj.org/toc/2150-7511ABSTRACT In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with numerous cotranscriptional processes that ultimately determine the transcript fate. Housekeeping NusG factors regulate expression of the bulk of the genome, whereas their highly specialized paralogs control just a few targets. In Escherichia coli, NusG stimulates silencing of horizontally acquired genes, while its paralog RfaH counters NusG action by activating a subset of these genes. Acting alone or as part of regulatory complexes, NusG factors can promote uninterrupted RNA synthesis, bring about transcription pausing or premature termination, modulate RNA processing, and facilitate translation. Recent structural and mechanistic studies of NusG homologs from all domains of life reveal molecular details of multifaceted interactions that underpin their unexpectedly diverse regulatory roles. NusG proteins share conserved binding sites on RNA polymerase and many effects on the transcription elongation complex but differ in their mechanisms of recruitment, interactions with nucleic acids and secondary partners, and regulatory outcomes. Strikingly, some can alternate between autoinhibited and activated states that possess dramatically different secondary structures to achieve exquisite target specificity.Irina ArtsimovitchStefan H. KnauerAmerican Society for MicrobiologyarticleNusGRfaHantiterminationtranscriptiontranslationMicrobiologyQR1-502ENmBio, Vol 10, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	NusG RfaH antitermination transcription translation Microbiology QR1-502
spellingShingle	NusG RfaH antitermination transcription translation Microbiology QR1-502 Irina Artsimovitch Stefan H. Knauer Ancient Transcription Factors in the News
description	ABSTRACT In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with numerous cotranscriptional processes that ultimately determine the transcript fate. Housekeeping NusG factors regulate expression of the bulk of the genome, whereas their highly specialized paralogs control just a few targets. In Escherichia coli, NusG stimulates silencing of horizontally acquired genes, while its paralog RfaH counters NusG action by activating a subset of these genes. Acting alone or as part of regulatory complexes, NusG factors can promote uninterrupted RNA synthesis, bring about transcription pausing or premature termination, modulate RNA processing, and facilitate translation. Recent structural and mechanistic studies of NusG homologs from all domains of life reveal molecular details of multifaceted interactions that underpin their unexpectedly diverse regulatory roles. NusG proteins share conserved binding sites on RNA polymerase and many effects on the transcription elongation complex but differ in their mechanisms of recruitment, interactions with nucleic acids and secondary partners, and regulatory outcomes. Strikingly, some can alternate between autoinhibited and activated states that possess dramatically different secondary structures to achieve exquisite target specificity.
format	article
author	Irina Artsimovitch Stefan H. Knauer
author_facet	Irina Artsimovitch Stefan H. Knauer
author_sort	Irina Artsimovitch
title	Ancient Transcription Factors in the News
title_short	Ancient Transcription Factors in the News
title_full	Ancient Transcription Factors in the News
title_fullStr	Ancient Transcription Factors in the News
title_full_unstemmed	Ancient Transcription Factors in the News
title_sort	ancient transcription factors in the news
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/92c9c2ae0c004a7696786d23e97d6ea8
work_keys_str_mv	AT irinaartsimovitch ancienttranscriptionfactorsinthenews AT stefanhknauer ancienttranscriptionfactorsinthenews
_version_	1718427231420678144

Ancient Transcription Factors in the News

Ejemplares similares