Bi-exponential 3D-T1ρ mapping of whole brain at 3 T

Abstract Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer’s, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rajiv G. Menon, Azadeh Sharafi, Johannes Windschuh, Ravinder R. Regatte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92ca165f6a404441af235168d2f81ca5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92ca165f6a404441af235168d2f81ca5
record_format	dspace
spelling	oai:doaj.org-article:92ca165f6a404441af235168d2f81ca52021-12-02T15:08:28ZBi-exponential 3D-T1ρ mapping of whole brain at 3 T10.1038/s41598-018-19452-52045-2322https://doaj.org/article/92ca165f6a404441af235168d2f81ca52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19452-5https://doaj.org/toc/2045-2322Abstract Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer’s, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40.5% of GM, and 65.1% of WM pixels showing two T1ρ relaxation pools (significance level P < 0.05). Detection of T1ρ based bi-exponential decays in the brain provides complimentary information to T2 based contrast regarding the in vivo micro-environment in the brain.Rajiv G. MenonAzadeh SharafiJohannes WindschuhRavinder R. RegatteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rajiv G. Menon Azadeh Sharafi Johannes Windschuh Ravinder R. Regatte Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
description	Abstract Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer’s, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40.5% of GM, and 65.1% of WM pixels showing two T1ρ relaxation pools (significance level P < 0.05). Detection of T1ρ based bi-exponential decays in the brain provides complimentary information to T2 based contrast regarding the in vivo micro-environment in the brain.
format	article
author	Rajiv G. Menon Azadeh Sharafi Johannes Windschuh Ravinder R. Regatte
author_facet	Rajiv G. Menon Azadeh Sharafi Johannes Windschuh Ravinder R. Regatte
author_sort	Rajiv G. Menon
title	Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
title_short	Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
title_full	Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
title_fullStr	Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
title_full_unstemmed	Bi-exponential 3D-T1ρ mapping of whole brain at 3 T
title_sort	bi-exponential 3d-t1ρ mapping of whole brain at 3 t
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/92ca165f6a404441af235168d2f81ca5
work_keys_str_mv	AT rajivgmenon biexponential3dt1rmappingofwholebrainat3t AT azadehsharafi biexponential3dt1rmappingofwholebrainat3t AT johanneswindschuh biexponential3dt1rmappingofwholebrainat3t AT ravinderrregatte biexponential3dt1rmappingofwholebrainat3t
_version_	1718388135678705664

Bi-exponential 3D-T1ρ mapping of whole brain at 3 T

Ejemplares similares