Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches
Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose.
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Nature Portfolio
2018
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oai:doaj.org-article:92caa47494d0490abeaced86358926822021-12-02T16:49:21ZEngineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches10.1038/s41467-018-02883-z2041-1723https://doaj.org/article/92caa47494d0490abeaced86358926822018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02883-zhttps://doaj.org/toc/2041-1723Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose.Xiaonan LiuJian ChengGuanghui ZhangWentao DingLijin DuanJing YangLing KuiXiaozhi ChengJiangxing RuanWei FanJunwen ChenGuangqiang LongYan ZhaoJing CaiWen WangYanhe MaYang DongShengchao YangHuifeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| description |
Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose. |
| format |
article |
| author |
Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang |
| author_facet |
Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang |
| author_sort |
Xiaonan Liu |
| title |
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_short |
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_full |
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_fullStr |
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_full_unstemmed |
Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_sort |
engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/92caa47494d0490abeaced8635892682 |
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